furin is a ca 2+ -dependent serine protease which cleaves proprotein substrates at the arg-xaa-(lys/arg)-arg    site to generate biologically active proteins. furin’s critical role in many cellular events associated with health disorders such as hiv, sars, anthrax, and influenza as well as cancer has made inhibitors of this enzyme as therapeutic targets. to this date, the most potent inhibitor ...

peptide and protein drugs have found an important position in therapeutics. recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. as these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. the twenty different naturally occurring amino ac...

background and objective: oxidative stress, due to free radicals, brings injury to the body by attacking large molecules and cell organs, and is the main reason of many diseases. fermentation of foods containing large amount of proteins such as milk by special species of lactic acid bacteria is a potential way in enhancement of the antioxidative activity of foods. this study aimed at evaluating...

Cancer is one of the causes of death in the world. Several treatment methods exist against cancer cells such as radiotherapy and chemotherapy. Since traditional methods have side effects on normal cells and are expensive, identification and developing a new method to cancer therapy is very important. Antimicrobial peptides, present in a wide variety of organisms, such as plants, amphibians and ...

background and objectives: regarding the importance of finding new antibacterial drugs, screening of plants as a promising resource are now conducted worldwide. in this study, we report the application of a simple previously described method for screening of different plant seeds in order to find the best resources of plant antimicrobial peptides. materials and methods: total water soluble prot...

objective(s): the objectives of this work was to assess the benefits of the application of physiologically based pharmacokinetic (pbpk) models in patients with different neuroendocrine tumours (net) who were treatedwith lu-177 dotatate. the model utilises clinical data on biodistribution of radiolabeled peptides (rlps) obtained by whole body scintigraphy (wbs) of the patients.methods: the blood...

cancer is one of the causes of death in the world. several treatment methods exist against cancer cells such as radiotherapy and chemotherapy. since traditional methods have side effects on normal cells and are expensive, identification and developing a new method to cancer therapy is very important. antimicrobial peptides, present in a wide variety of organisms, such as plants, amphibians and ...