Periapical disease caused by the colonization of microrganisms in the root canal system. Microbiology implicated in endodontic disease is diverse and varied. Mircobial testing of periapical lesions can be traced back to 1890. The changes in balance of the microbiota along with other factors host resistance and viral infection can also affect the periapical disease. The various microbiology invo...

AIM To compare the diagnostic accuracy of intraoral digital periapical radiography with that of cone beam computed tomography (CBCT) for the detection of artificial periapical bone defects in dry human jaws. METHODOLOGY Small and large artificial periapical lesions were prepared in the periapical region of the distal root of six molar teeth in human mandibles. Scans and radiographs were taken...

A major paraclinical diagnostic method for the early and late follow-up of the healing process in chronic periapical lesions is the two-dimensional radiographic technique. About 32% of the periapical lesions are detected during a routine radiographic examination of neighboring teeth. Most of the periapical lesions are classified as granulomas, cysts and abscesses. The radiographic images of the...

The aim of this study was to accomplish quantitative measurement of tissue levels of collagenases (MMP-1, 8 and 13) in chronic inflamed tissues (pulp and periapical lesions), as well as to determine the dependence between collagenase level and the degree of tissue destruction of examined material. Chronic periapical tissues were collected by periapical surgery from 50 teeth with clinically and ...

Macrophages are major constituents of periapical granulomas. They have a central protective role in both innate immunity and adoptive, antigen-specific immune response. Macrophage activation may occur in periapical granulomas by cytokines produced by antigen-activated T-lymphocytes; by bacterial endotoxin, as part of the innate immunity; or by both these processes. Recent studies in athymic ani...

The presence of Enterococcus faecalis in root canal teeth affected by primary and secondary periapical lesions was studied using polymerase chain reaction (PCR) assays. The association between presence of E. faecalis with clinical signs of apical lesions was assessed to evaluate a possible relationship between clinical findings. Microbial samples were obtained from healthy patients affected by ...

INTRODUCTION A significant number of endodontically treated teeth restored with posts have associated periapical lesions, and several authors have discussed the probable causes of the development of these. Attention has been focused on restorative procedures performed after endodontic treatment and their association with the prognosis of endodontic therapy because a number of root-filled teeth ...