BACKGROUND/AIM Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading almost all extracellular matrix and basement membrane components in many destructive pathological processes, such as chronic inflammation and bone-destructive lesions. The aim of this study was to determinate the correlation between concentration of collagenases (MMP-1, -8, -13) in chronic periapical le...

BACKGROUND Leptin, initially described as an adipocyte-derived hormone to regulate weight control, is expressed in normal and inflamed human dental pulp, being up-regulated during pulp experimental inflammation. Leptin receptor (LER) has been identified in human periapical granulomas. The aim of this study was to analyze and characterize the expression of leptin in human periapical granulomas. ...

Wound healing following periapical surgery is influenced by age, gender, smoking, lesion size, type of root-end filling, method cavity preparation and the use microsurgical or conventional technique. This study aimed to evaluate influence various preoperative factors such as pain, size on outcome surgical endodontic treatment. A thorough history, examination, investigation were performed establ...

AIM To report a case of conservative nonsurgical management of periapical lesions. BACKGROUND Small periapical lesions of endodontic origin usually heal by conventional endodontic therapy alone. Larger periapical lesions presumed to be cystic may require additional treatment protocols to aid in regression. Conservative nonsurgical management of such lesions eliminates the possible complicatio...

OBJECTIVES Our aim was to compare periapical radiography and cone beam CT (CBCT) for assessment of the periapical bone defect 1 week and 12 months after root-end resection. METHODS 50 patients (58 teeth) with a persisting apical periodontitis in a root-filled tooth (incisor, canine or premolar) were treated with root-end resection. 1 week and 12 months post-operatively, a CBCT scan (NewTom 3G...

Introduction. This paper describes a case of bone augmentation with combination of Platelet-Rich Fibrin (PRF) and β-TCP for treatment of chronic periapical cyst. The case was followed for 12 months. Methods. Patient presented with chronic periapical lesion in maxillary anterior teeth with history of trauma 8 years back. Radiographically, a periapical cyst was seen in relation to maxillary left ...

Introduction: Mineral trioxide aggregate (MTA) has a variety of possible uses, including root-end filling material due to its excellent sealing ability in the presence of moisture and a high degree of biocompatibility. Aim: This case report demonstrates the use of MTA as an obturating material to promote periapical healing of root canals with large apical rarefactions. Materials and Methods: An...

Traumatic injuries commonly affect the anterior teeth leading to slow death of the pulp. This may give rise to a periapical or radicular cyst which results from the proliferation of cell rests of Malassez following pulpal necrosis of a nonvital tooth. This condition is usually asymptomatic but can result in a slow-growth tumefaction in the affected region. On radiography the lesion can be seen ...

In teeth with periapical lesions and defective root canal seals non-surgical retreatment is usually preferred. Sometimes, however, such treatment may not be feasible and periapical surgery must be performed. The present study investigated a technique of retrograde root canal treatment as an alternative to the more conventional types of surgical procedure. The material consisted of 35 teeth whos...

This paper describes and discusses the multidisciplinary treatment involving a permanent maxillary lateral incisor fused to a supernumerary tooth, both presenting pulp necrosis and periapical lesion. A 15-year-old male patient sought treatment complaining of pain, swelling and mobility on the maxillary right lateral incisor. After clinical and radiographic examination, root canal preparation wa...