نتایج جستجو برای: periodontitis ketoprofen
تعداد نتایج: 13079 فیلتر نتایج به سال:
This study aims to improve the dissolution rate of ketoprofen by preparing multicomponent crystals with tromethamine. The (equimolar ratio) and tromethamine were prepared solvent co-evaporation method. solid-state properties resulting powder characterized X-ray diffraction, DSC thermal analysis, FT–IR spectroscopy, solubility, in vitro rate. crystal structure was determined single-crystal diffr...
The activation of ketoprofen, which inhibits the outgrowth of azoxymethane-induced aberrant crypt foci in the rat colon, on the inhibition of arylamine N-acetyltransferase (NAT) activity (N-acetylation of substrates), gene expression (mRNA NAT) and 2-aminofluorene (AF)-DNA adduct formation was studied in a human colon tumor (adenocarcinoma) cell line (colo 205). Cellular cytosols (9000 xg super...
R-(-)-2-(3(prm1)-Benzoylphenyl)propionic acid [R-(-)-ketoprofen] was produced from racemic 2-(3(prm1)-benzoylphenyl)propionamide (keto-amide) by the isolated bacterial strain Comamonas acidovorans KPO-2771-4. Sodium fumarate as the carbon source and 2-azacyclononanone or isobutyronitrile as the enhancer in the culture medium were effective for bacterial growth and the enhancement of R-(-)-ketop...
OBJECTIVE To compare the ketoprofen TDS patch with diclofenac gel in the treatment of traumatic acute pain in benign sport-related soft-tissue injuries. DESIGN 7-14 treatment days, prospective, randomised, open study. PATIENTS Outpatients aged 18-70 years diagnosed for painful benign sport-related soft-tissue injury (sprains, strains and contusions within the prior 48 h), randomised to eith...
This study describes the in vitro degradation studies of the diastereomeric ketoprofen glucuronides, under physiological conditions (pH 7.4, 37°C, (R)-ketoprofen glucuronide t1⁄2 = 30 min, (S)-ketoprofen glucuronide t1⁄2 = 70 min) and the irreversible binding of diastereomeric ketoprofen glucuronides (15 μg/ml) to human serum albumin (HSA) (289 μM) and human plasma under physiological condition...
A comparative, multi-centre study, was conducted during June to December, 1996 to evaluate the efficacy and tolerance of Ketoprofen 100 mg Enteric Coated (EC) tablet and 100 mg intra-muscular injection; with that of Diclofenac Sodium 50 mg tablet and 75 mg intra-muscular injection in acute rheumatic and traumatic disorders. Total of 180 patients (90 per drug), were studied, 82 men and 98 women,...
OBJECTIVE To evaluate the safety and efficacy of ketoprofen in Transfersome® gel (IDEA-033) in comparison with a ketoprofen-free vehicle (TDT 064) for the treatment of osteoarthritis (OA) of the knee. METHODS Patients with knee OA (N = 866) were randomly assigned to receive topical IDEA-033 containing 100, 50, or 25 mg ketoprofen, or TDT 064 twice daily for 12 weeks, in a double-blind trial. ...
A double-blind cross-over study of ketoprofen (Orudis) 150 mg daily and ibuprofen (Brufen) 1,200 mg daily was carried out in 35 outpatients with rheumatoid arthritis. Results suggest that analgesic and anti-inflammatory activity of ketoprofen is superior to that of ibuprofen. Significantly greater pain relief (P < 0.05) and reduction in joint circumference (P < 0.01) was obtained with ketoprofe...
introduction: ketoprofen is an nsaid and selective cox-1 inhibitor. in our previous study the role of flunixin meglumine, a nonselective cox inhibitor was studied on seizure and its anticonvulsant effects were confirmed. therefore this research is performed to assess the role of a selective cox-1 inhibitor, ketoprofen in treatment of seizures induced by ptz. methods: in this research, male wist...
The purpose of the study was to investigate the stability and biopharmaceutical characteristics of ketoprofen, loaded in polymeric carriers, which were included into a bigel in a semisolid dosage form. The polymer carriers with in situ-included ketoprofen were obtained by emulsifier-free emulsion polymerization of the monomers in aqueous medium or a solution of the polymers used. The morphologi...
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