We present a case of a solitary neurofibroma involving the right posterior shoulder of a 69-year-old man with degeneration into a massive, malignant peripheral nerve sheath tumor measuring more than 3 times the average reported size. The radiographic, magnetic resonance imaging, and computed tomographic features are compared with the gross appearance and pathology.

A malignant peripheral nerve sheath tumor (MPNST) is an extremely rare soft tissue tumor in the general population. On the other hand, there is a higher incidence of MPNST in patients with neurofibromatosis type I (von Recklinghausen's disease). The common sites are the extremities, trunk, head and neck. However, an intraabdominal or intrathoracic manifestation is uncommon. This paper reports t...

Neurofibromatosis type 2 is an inherited disease. The main manifestation of the disease is the development of symmetric, non-malignant brain tumors in the region of the cranial nerve VIII usually as schwannoma. We report here a 20-year-old woman with primary intracranial malignant nerve sheath tumor located in the left cerebellopontine angle. Histologically, the tumor showed malignant spindle c...

abstract introduction & objective: schwannoma, a benign tumor of nerve sheath origin, is commonly found in the head and neck, as well as flexor surfaces of the extremities. it can rarely occur in the breast and stomach with only a few cases being reported. case reports:   the cases are: 1) a 57-year- old man with breast mass, 2) a 58 -year -old man with gastrointestinal complaints who were fina...

neurofibromatosis type 2 is an inherited disease. the main manifestation of the disease is the development of symmetric, non-malignant brain tumors in the region of the cranial nerve viii usually as schwannoma. we report here a 20-year-old woman with primary intracranial malignant nerve sheath tumor located in the left cerebellopontine angle. histologically, the tumor showed malignant spindle c...

Malignant peripheral nerve sheath tumors (MPNSTs) are very rare sarcomas derived from various cells in the peripheral nerve sheath. Malignant peripheral nerve sheath tumors have a known association with neurofibromatosis type 1. Diagnosis of MPNSTs is difficult in patients with chronic pain, when MPNST occurs at an overlapping area of chronic pain. Therefore, the diagnosis can be missed unless ...

Peripheral nerve sheath tumors are benign tumors that have the potential to transform into malignant peripheral nerve sheath tumors (MPNSTs). Interleukin-13 receptor alpha 2 (IL13Rα2) is a cancer associated receptor expressed in glioblastoma and other invasive cancers. We analyzed IL13Rα2 expression in several MPNST cell lines including the STS26T cell line, as well as in several peripheral ner...

Malignant peripheral nerve sheath tumors of the scalp are rare lesions of the nervous system. Only 16 cases have been reported to date. In this report, we present a case of a malignant peripheral nerve sheath tumor (MPNST) of the scalp and retrospectively analyze the clinical features, imaging findings, pathological features, and prognoses of these tumors.

Schwannoma is a benign encapsulated nerve sheath tumor composed of Schwann cells, that may arise anywhere along the course nerve. Cutaneous schwannomas, associated with peripheral nerves, usually present as slow-growing well-circumscribed nodule, localized in dermis or subcutaneous tissue. They are generally asymptomatic; however, they become painful by nervous compression. Since clinical signs...

1. Evans DG, Baser ME, McGaughran J, et al. Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet 2002;39:311-4. 2. Wallace MR. Neurofibromatosis: phenotype, natural history, and pathogenesis, 3rd ed. edited by J. M. Friedman, David H. Gutmann, Mia MacCollin, and Vincent M. Riccardi. Baltimore: Johns Hopkins Press, 1999. Pp. 380. $99.95 (hardcover only). Am J Hum Genet 2...