The prerequisites of peripheral activation of self-specific CD4(+) T cells that determine the development of autoimmunity are incompletely understood. SJL mice immunized with myelin proteolipid protein (PLP) 139-151 developed experimental autoimmune encephalomyelitis (EAE) when pertussis toxin (PT) was injected at the time of immunization but not when injected 6 days later, indicating that PT-i...

Pterocarpans are known to have antifungal and anti-inflammatory properties. However, little is known about the changes in transcriptional profiles in response to a pterocarpan-high soybean leaf extract (PT). Therefore, this study investigated the effects of PT on blood glucose and lipid levels, as well as on the inflammation-related gene expression based on a peripheral blood mononuclear cells ...

Ten adult humans were vaccinated with the Japanese acellular pertussis vaccine JNIH-3, containing detoxified pertussis toxin (PT), formaldehyde, and filamentous hemagglutinin. The vaccination induced a specific antibody response to PT and filamentous hemagglutinin, and a Western blot (immunoblot) analysis of the antibody response to PT revealed antibodies to PT subunits S1, S2, S3, S4 and S5. T...

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Eigenvalues of a potential dynamical system with damping forces that are described by an indefinite real symmetric matrix can behave as those of a Hamiltonian system when gain and loss are in a perfect balance. This happens when the indefinitely damped system obeys parity-time ( ) symmetry. How do pure imaginary eigenvalues of a stable -symmetric indefinitely damped system behave when variation...

We examine the PT-symmetry-breaking transition for a magnetic metamaterial of a finite extent, modeled as an array of coupled split-ring resonators in the equivalent circuit model approximation. Small-size arrays are solved completely in closed form, while for arrays larger than N=5 results were computed numerically for several gain and loss spatial distributions. In all cases, it is found that...

The quantum mechanical brachistochrone system with a PT-symmetric Hamiltonian is Naimark-dilated and reinterpreted as a subsystem of a Hermitian system in a higher-dimensional Hilbert space. This opens a way to a direct experimental implementation of the recently hypothesized PT-symmetric ultrafast brachistochrone regime of Bender et al. [Phys. Rev. Lett. 98, 040403 (2007)] in an entangled two-...

PURPOSE We present the largest study of both peripheral blood and lymph node samples examining the utility of reverse transcription-polymerase chain reaction (RT-PCR) for established molecular markers as a diagnostic tool in the molecular staging of prostate cancer patients undergoing radical prostatectomy. EXPERIMENTAL DESIGN Peripheral blood from 358 patients was obtained before radical pro...

To evaluate ultrasonographic (US) cross-sectional areas (CSAs) of peripheral nerves, indexes of the differences between CSAs at the same point (∆CSAs) and between tunnel (T) and pre-tunnel (PT) ulnar CSAs (∆TPTs) in leprosy patients (LPs) and healthy volunteers (HVs). Seventy-seven LPs and 49 HVs underwent bilateral US at PT and T ulnar points, as well as along the median (M) and common fibular...