Prussian Blue (ferric hexacyanoferrate (II)), discovered accidentally in 1706 in Berlin by Johann Jacob Diesbach (1) and Johann Konrad Dippel (2), remains an intensively investigated material. Currently, more than 200 scientific publications with Prussian Blue as a research subject are published annually. Johann Leonhard Frisch (see below) and Diesbach produced Prussian Blue in the years follow...

The timing of the breakdown of red blood cells and organization of hemorrhage has significance in the catabolism of heme and the processing of iron, but also has a practical application in terms of assigning, or attempting to assign, a time course with respect to traumatic events (e.g. contusions and hemorrhages). Attempts to date contusions, however, have generally been unsuccessful by macrosc...

INTRODUCTION Many investigators report that Prussian blue is effective on removing radiocesium from the body. However, we does not agree with the results obtained from the animal experiments, because administration methods on Prussian Blue administration used in these experiments, e.g., dose, route, initial time, resulting in superior effects are marked different from the conditions in the huma...

Splenectomy is a recognized therapy for liver cirrhosis with splenomegaly, since it decreases free iron concentration that accompanies the destruction of red blood cells. Heme oxygenase (HO)-1 and its by-products, iron and carbon monoxide (CO), play crucial roles in hepatic fibrosis. The aim of the present study was to determine whether splenectomy in cirrhotic rats induced by bile duct ligatio...

A public trout hatchery in Colorado recorded repeat episodes of morbidity and mortality early life stages Rainbow Trout (Oncorhynchus mykiss) stocks. The water source for the affected tanks is a groundwater well with pH 6.3 ferrous iron concentration 120 µg/L. Iron oxidizing bacteria (FeOB) were suspected as underlying cause due to insoluble red particulate matter (iron oxide precipitate) water...

The aim of this study was to trace the Fe uptake pathway in leaves of Prunus rootstock (GF 677; Prunus dulcis × Prunus persica) plants treated with foliar Fe compounds using the Perls blue method, which detects labile Fe pools. Young expanded leaves of Fe-deficient plants grown in nutrient solution were treated with Fe-compounds using a brush. Iron compounds used were the ferrous salt FeSO4, th...

OBJECTIVE This study aimed to evaluate the hypotheses that administration routes [intra-arterial (IA) vs. intravenous (IV)] affect the early stage migration of transplanted human bone marrow-derived mesenchymal stem cells (hBM-MSCs) in acute brain infarction. METHODS Male Sprague-Dawley rats (n=40) were subjected to photothrombotic infarction. Three days after photothrombotic infarction, rats...

CONTEXT Prussian blue, ferric hexacyanoferrate is approved for (oral) treatment of internal contamination with radioisotopes of cesium or thallium. Cyanide makes up 35-40% of Prussian blue's molecular composition; thus, cyanide may be released during transit through the digestive tract under physiological pH conditions. OBJECTIVES The purpose of this study is to assess the long-term stability...

Iron within atherosclerotic plaque has been implicated as a catalyst of oxidative stress that causes progression of plaque, and plaque rupture. Iron is believed to accumulate within plaque by incorporation of erythrocytes following plaque rupture and hemorrhage. There is only indirect evidence to support this hypothesis. Plaque specimens were obtained from ten symptomatic and fifteen asymptomat...