objective: the risk of cardiac death in diabetic patients is 3 times more than non-diabetics. but it is not determined who need cardiac screening. about 41% of diabetic patients with silent ischemia are missed. the carotid intima-media thickness (cimt) and ankel brachial index are two independent,simple and non invasive method in vascular complications diagnosis in diabetic patients.the aim of ...

Current rodent models of ischemia/infarct or pressure-volume overload are not fully representative of human heart failure. We developed a new model of congestive heart failure (CHF) with both ischemic and stress injuries combined with fibrosis in the remote myocardium. Sprague-Dawley male rats were used. Ascending aortic banding (Ab) was performed to induce hypertrophy. Two months post-Ab, isch...

Chen J, Chemaly ER, Liang LF, LaRocca TJ, Yaniz-Galende E, Hajjar RJ. A new model of congestive heart failure in rats. Am J Physiol Heart Circ Physiol 301: H994–H1003, 2011. First published June 10, 2011; doi:10.1152/ajpheart.00245.2011.—Current rodent models of ischemia/infarct or pressure-volume overload are not fully representative of human heart failure. We developed a new model of congesti...

in the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. the hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. in the control group, the hearts were perfused by normal drug free krebs-henseleit (k/h) solution t...

introduction: the present study evaluated morphological changes of ca1 hippocampal neurons following transient bilateral common carotid and permanent left middle cerebral arteries occlusion, also the neuroprotective effects of aspirin i.p injection was inducing assessed after ischemia in male rat. material and methods: in this experiment, 4 groups of animals were used including; control, sham, ...

Caveolin (Cav)-1 has been involved in the pathogenesis of ischemic injuries. For instance, modulations of Cav-1 expression have been reported in animal models of myocardial infarction and cerebral ischemia-reperfusion. Furthermore, ablation of the Cav-1 gene in mice has been shown to increase the extent of ischemic injury in models of cerebral and hindlimb ischemia. Cav-1 has also been suggeste...

Cardiac arrest (CA) is a medical emergency defined as sudden and unexpected cessation of vital functions, characterized by absence of heart beats, respiratory movements and unresponsiveness to stimuli.(1) Nevertheless the development of reanimation maneuvers, mortality of cardiac arrest patients remains high.(2,3) Cardiac arrest produces sudden brain blood flow cessation, causing neuronal ische...