bordetella pertussis is a gram negative bacterium that causes respiratory tract infection in human (whooping cough). pertussis toxin (pt) is the main component of current acellular pertussis vaccine and the s1 (subunit1) is the main immunogenic part of it. thus, s1 has been the target of many studies as a potent candidate of acellular vaccine against bordetella pertussis, lacking the side effec...

Persistence of immune memory in humans is a crucial yet poorly understood aspect immunology. Here we have studied the effect Puumala hantavirus infection on unrelated, pre-existing by studying T cell- and antibody responses against toxoid vaccine antigens diphtheria, tetanus pertussis cohort 45 patients. We found that tetanus- -specific IgG concentrations elevate during acute virus infection. I...

background pertussis is a highly communicable, vaccine-preventable respiratory disease; which may circulate even in populations with high vaccination coverage. although frequent, but it is often underestimated as a cause of prolonged cough illness in both children and adults. without boosting, the protection of the childhood vaccination would be minimal after 10 years. the need for adult booste...

background and objective: due to contagiousness of pertussis, a rapid and sensitive method for diagnosis is required to initiate the treatment and interrupt its transmission. materials and methods: to detect b. pertussis strains, we used two real-time pcr targeting is 481 and bp283 sequences and compared factors influencing culture and real-time pcr results. results: totally, 779 specimens were...

Objective(s): After decades of containment, pertussis disease, caused by Bordetella pertussis seems to be re-emerging and still remains a major cause of reported vaccine-preventable deaths worldwide. The current licensed whole-cell vaccines display reactogenicity while acellular vaccines are expensive and do not induce Th1-type immune responses that are required for optimum protection against t...

Abstract Background Although Respiratory syncytial virus (RSV) is one of the common pathogens in children with pertussis and viral coinfection, clinical impact RSV infection on remains unclear. We compared characteristics sought differences between infants single Bordetella ( B. ) those coinfection. Methods enrolled 80 patients who were hospitalized Shenzhen Children’s Hospital from January 201...

Respiratory tract infections (RTIs) are a major public health concern. This study aims to investigate the profiles and epidemiological characteristics of acute RTIs respiratory pathogens in Palestinian hospitalized patients. Clinical samples from patients with symptoms admitted between January 2011 December 2016 were referred Central Public Health Laboratory (PHCL) identify causative pathogen. ...

Relatively few epidemiological studies have utilized Random Forests (RF), possibly because the time series data often encountered in this discipline are perceived as unsuitable for supervised learning methods. We show RF can be used such data, and demonstrate an example examining which social activities influence pertussis. Results compared with regression ARIMA errors modelling. Pertussis cont...