a-Latrotoxin binding to the calcium-independent receptor for a-latrotoxin (CIRL-1), a putative G-protein-coupled receptor, stimulates secretion from chromaffin and PC12 cells. Using patch clamp techniques and microspectrofluorimetry, we demonstrate that the interaction of a-latrotoxin with CIRL-1 produces a high conductance channel that permits increases in cytosolic Ca. a-Latrotoxin interactio...

Virtual libraries used in molecular discovery are often too large to exhaustively evaluate, warranting the use of algorithms help with exploration.Algorithmic approaches like Bayesian optimization can efficiently navigate predefined chemical spaces combination surrogate models.On-the-fly generation during exploration enables even larger be searched, including deep-learning-based models, althoug...

Achieving the Paris Agreement 1.5°C target requires a reversal of growing atmospheric concentrations methane, which is about 80 times more potent than CO2 on 20-year timescale. The Intergovernmental Panel Climate Change (IPCC) Sixth Assessment Report stated that methane underregulated, but little known effectiveness existing policies. In this review, we systematically examine policies across en...

s 1/18/16 A. Development of the Nervous System Class-6 Semaphorins have receptor function during neural circuit formation A6 Authors Vlad Karas (1), Irwin Andermatt (1), Olivier Mauti (1), Esther Stoeckli (1) Affiliations 1) University of Zurich Class-6 Semaphorins form a transmembrane subgroup of the Semaphorin family. They were implicated in various processes, such as differentiation, cell mi...