Phage therapy has been a centre of attraction for biomedical scientists to treat infections caused by drug resistant strains. However, ability of phage to act only on extracellular bacteria and probability of interference by anti-phage antibodies in vivo is considered as a important limitation of bacteriophage therapy. To overcome these hurdles, liposome were used as delivery vehicle for phage ...

Background: Salmonella, a bacterial genus of more than 2500 serotypes is considered as the most significant foodborne pathogen causing infections in humans and animals. Increased antimicrobial resistance and persistence of antimicrobial residues in food matrices warrants the need for alternative infection management strategies. Aims: The present study aimed to isolate and evaluate the lytic act...

background: prostate cancer after lung cancer is the second cause of cancer-associated death in men. in recent years, targeted therapy of cancer has attracted researchers attention. the targeted therapy lead to decrease in side effects of drugs. studies have indicated that targeting peptides for cancer cells represent valuable tools for diagnostic and therapeutic. recently, phage display peptid...

Bacteriophage (phage) therapy is expected to become an alternative therapy for Pseudomonas aeruginosa infections. P. aeruginosa phage KPP23 is a newly isolated phage belonging to the family Siphoviridae and may be a therapeutic phage candidate. We report its complete genome, which comprises 62,774 bp of double-stranded DNA containing 95 open reading frames.

Background: Increasing antibiotic resistance warrants therapeutic alternatives to eradicate resistant bacteria. Combined phage-antibiotic therapy is a promising approach for eliminating bacterial infections and limiting the evolution of therapy-resistant diseases. Objectives: In present study, we evaluated effects combinations bacteriophages antibiotics against multidrug-resistant (MDR) Klebsie...

Abstract Today, the clinical potential of antibiotics is almost exhausted, which has led to a renaissance phage research and therapy. To maximize therapy efficiency, we need an in-depth understanding molecular mechanisms by phages fight their hosts. Omics technologies can provide valuable insights in processes infection. We applied time-resolved proteomics transcriptomics characterize T4 infect...

In the context of bacteriophage (phage) therapy, there is an urgent need for a method permitting multiplexed, parallel phage susceptibility testing (PST) prior to formulation personalized cocktails administration patients suffering from antimicrobial-resistant bacterial infections. Methods based on surface plasmon resonance imaging (SPRi) and phase were demonstrated as candidates very rapid (&l...

Current insights into the close relationship between human health and gut microbiota, as well recent advances in molecular biology suggesting a significant role for viromas, have encouraged research therapeutic usefulness of bacteriophages. The purpose this review is to consider prospects use bacteriophages correction microbiota therapy digestive system diseases. describes basics phage biology,...

The concept of phage therapy to treat bacterial infections was born with the discovery of the bacteriophage almost a century ago. After a chequered history, its current renaissance is fueled by the dangerous appearance of antibiotic-resistant bacteria on a global scale. As a mark of this renewed interest, the unanswered problems of phage therapy are now being addressed, especially for human use...