نتایج جستجو برای: phagocyte disorders
تعداد نتایج: 673312 فیلتر نتایج به سال:
Background: Diabetes is a hidden epidemic and the most common metabolic disorder in the world. Immune dysfunction (cellular and humoural) is one of the consequences of diabetes, including defects of phagocyte function, notably in chemotaxis, phagocytosis, and killing. Results of studies on phagocyte respiratory burst activity, however, have been contradictory. We studied the respiratory burst o...
In the majority of neurodegenerative storage disorders, neuronal death in the brain is followed by infiltration of phagocytic cells (e.g. activated microglia, astroglia and macrophages) for the efficient removal of cell corpses. However, it is increasingly evident that these phagocytes may also cause death of adjoining viable neurons contributing to rapid progression of neurodegeneration. Infan...
Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPα and its ligand CD47 are involved in phagocyte transendothelial migration. We have investigated the involvement of SIRPα signaling in phagocyte migration in vitro and in vivo using mice that lack the SIRPα...
Although the ability of mononuclear phagocytes to interact with basement membranes and other extracellular matrices is well documented, the mechanisms involved and their possible modes of regulation are poorly understood (1) . Monocytes must penetrate the basement membranes of vascular endothelia during their emigration from blood to tissue (1) and they can encounter basement membranes again af...
Adhesins facilitate bacterial colonization and invasion of host tissues are considered virulence factors, but their impact on immune-mediated damage as a driver pathogenesis remains unclear. Yersinia pseudotuberculosis encodes for multivalent adhesion molecule (MAM), mammalian cell entry (MCE) family protein adhesin. MAMs widespread in Gram-negative bacteria enable enteric to colonize epithelia...
Radiation and polychemotherapy significantly affect the immune system of a cancer patient, unabling to adequately respond infectious agents provide effective antitumor protection. Rehabilitation disorders is an urgent task, solution which will contribute generalization experience when suing modulators in patients. To summarize existing data on use concomitant therapy treatment, reports publishe...
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