In pharmaceutical bioanalysis, researchers develop and run various assays to quantitate drugs, pharmaceutical candidates, and their metabolites in biological fluids such as serum and plasma. The data resulting from these assays are used to help determine the pharmacodynamic and pharmacokinetic properties as well as the toxic and therapeutic concentrations of existing and emerging pharmaceutical...

There are errors in the Funding section. The correct funding information is as follows: A research grant from Aichi Kidney Foundation, YH. The COE for education and research of Micro-Nano Mechatronics Nagoya University Global COE Program, YH KH. Funding was also received from Kyowa Hakko Kirin Co., Ltd; Otsuka Pharmaceutical Co.,Ltd; Dainippon Sumitomo Pharma Co., Ltd; and MOCHIDA PHARMACEUTICA...

The term 'generic prescribing' describes the use in prescribing of a non-proprietary title for a pharmaceutical preparation. The non-proprietary titles in the British National Formulary (BNF) are often titles from the European Pharmacopoeia, British Pharmacopoeia or British Pharmaceutical Codex 1973. In this way we know that the preparations prescribed by non-proprietary title must comply with ...

Pharmaceutical co-crystal formation represents a straightforward way to dramatically influence the solid-state properties of a drug substance, particularly its solubility and hence bioavailability. This short review summarises this highly topical field, covering why the topic is of interest in pharmaceutical formulation, the definitions and practical scope of co-crystals, co-crystal preparation...

Immunoassays are bioanalytical methods in which the quantitation of the analyte depends on the reaction of an antigen (analyte) and an antibody. Immunoassays have been widely used in many important areas of pharmaceutical analysis such as diagnosis of diseases, therapeutic drug monitoring, clinical pharmacokinetic and bioequivalence studies in drug discovery and pharmaceutical industries. The i...

The preparation of stable amorphous pemetrexed disodium of pharmaceutical purity as well as the process optimization for the preparation of the hemipentahydrate form of pemetrexed disodium are described. Analytical methods for the polymorphic and chemical purity studies of pemetrexed disodium and pemetrexed diacid forms were developed. The physicochemical properties of the amorphous and hydrate...

PURPOSE To review microbial contamination rates about preparation of individual and batch doses using aseptic techniques within pharmaceutical (controlled) and clinical (ward and theatre) environments. METHODS Systematic review, involving amalgamation of data using a random effect model and metaanalysis. RESULTS A total of 19 studies from 17 reports (7277 doses), mostly single arm studies, ...

The considerable importance of ?-arylated carbonyl compounds, which are widely used in the pharmaceutical industry, has prompted efficient synthetic strategies for their preparation.