We describe a reliable gas-chromatographic analysis for unchanged phencyclidine in human plasma, with use of a nitrogen detector. The assay is sufficiently sensitive to permit measurement of as little as 5 microgram of the drug per liter, in 2 mL of plasma. Phencyclidine is extracted from plasma at pH 10.5 into hexane/iso-amyl alcohol containing meperidine as the internal standard, back-extrac...

Phencyclidine which is chemically similar to ketamine was introduced into clinical practice in 1958. Although phencyclidine proved useful as an anaesthetic, it produced severe adverse psychological effects in the recovery period. Ketamine, then named C1581, is one of 200 phencyclidine derivatives which were investigate subsequently and proved to be the most promising. It was synthesized as Keta...

Phencyclidine and ketamine induce in humans a profound change in central nervous system function that resembles anesthesia, i.e., loss of sensitivity to pain and a total amnesia for events during intoxication. Ketamine continues to be used in medicine as an anesthetic in many places in the world and is used in the U.S. extensively in children when burn wounds are treated. In many different spec...

Phencyclidine (PCP) mimics many aspects of schizophrenia, yet the underlying mechanism of neurochemical adaptation for PCP is unknown. We therefore used proteomics to study changes in the medial prefrontal cortex in animals with PCP-induced behavioural deficits. Male Wistar rats were injected with saline or 5 mg/kg phencyclidine for 5 days followed by two days of washout. Spontaneous alternatio...

According to the report by United Nations Office on Drugs and Crime (2020), number of drug-users aged 12-64 has exceeded 275 million people, which accounts for 5.4% globe’s population. The highest drug addicts been registered in States America − 28.6 million; European Union – 17.4 million, while Russia 6 with 11.8 deaths annually worldwide, that are directly or indirectly related abuse. Tighten...

R.E. SOLOMON, S. HERLING and J.H. WOODS, Discriminative stimulus effects of monohydroxylated phencyclidine metabolites in rhesus monkeys, European J. Pharmacol. 82 (1982) 233-237. Rhesus monkeys were trained to discriminate saline from an injection of ketamine. In tests of stimulus generalization, phencyclidine (PCP) produced dose-related ketamine-appropriate responding in each monkey. Two mono...