A micellar electrokinetic chromatographic (MEKC) method has been established for the identification and determination of acid-catalyzed proanthocyanidin cleavage products in the presence of phloroglucinol. Using fused-silica capillaries (50=57 cm, 22 kV) with phosphate buffer containing sodium dodecyl sulfate as the surfactant and b-cyclodextrin as modifier, structurally similar phloroglucinol ...

BACKGROUND Abdominal pain is the predominant symptom in irritable bowel syndrome patients. Phloroglucinol and its methylated derivative are antispasmodic agents acting on smooth muscle. AIM To evaluate the efficacy of phloroglucinol/trimethylphloroglucinol on pain intensity during an acute exacerbation of pain of irritable bowel syndrome over a 1-week period treatment. METHODS Irritable bow...

The composition and significance of physodes, brown algal subcellulai bodies characterized by reactivity with vanillin-hydrochloric acid, have been the subject of debate for the past Century. This research is critically reviewed, and it is demonstrated that aJthough physodes aie primarily composed of phloroglucinol derivatives, they may also contain other tannins and terpenes. The recent discov...

Six strains were isolated from Lake Akşehir (Konya-Turkey) and identified as Rhodopseudomonas palustris on the basis of physiological and morphological characteristics. The strains grew phototrophically on a variety of aromatic compounds (under illuminated anaerobic conditions), namely, benzoate, hippurate, benzyl alcohol, 2-amino benzoic acid, phloroglucinol, phenylacetic acid, catechol, pyrid...

Studies on structure/activity relationships o f phloroglucinol derivatives tha t had been de­ signed based on the structures o f grandinol and hom ograndinol. potent photosystem II (PS II) inhibitors in Eucalyptus grandis, revealed th a t two electron-withdraw ing groups which differ by their electron-w ithdraw ing pow er on a phloroglucinol nucleus were essential for activity. A larger differe...

INTRODUCTION Phloroglucinol is an antioxidant compound with many positive effects on health. The purpose of this study was to determine the role of phloroglucinol in osteoclastogenesis via the RANKL/RANK signaling pathway and the activity of the transcription factor Nrf2. MATERIAL AND METHODS Analysis was performed in silico using the primary method of docking by the use of Hex 8.0 software a...

1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. This compound is synthesized in three successive methylation steps from phloroglucinol, the initial precursor. A novel, to our knowledge, phloroglucinol O-methyltransferase (POMT) characterized here methylates the first step to produce the intermediate 3,5-dihydroxyanisole, while two previously described orcinol O-methyltransf...

By Sephadex LH-20 gel chromatography of an extract from Gingko biloba leaves, polymeric proanthocyanidins were eluted after the fractions of flavonol glycosides and biflavone glycosides. A purified proanthocyanidin polymer accounted for 86.6% of the total proanthocyanidins, and for 37.7% of the total antioxidant activity of this leaf extract. For structure elucidation, the polymer was submitted...

A method for molecular-level quantification of condensed tannin is described that uses acid depolymerization and carbocation capture by phloroglucinol. Resulting monomers and phloroglucinol adducts are trimethylsilyl derivatized, separated by capillary gas chromatography, detected by flame ionization, and quantified relative to standards. Optimal depolymerization conditions were determined for ...

Phloroglucinol is a polyphenol compound with free radical scavenging, anti-inflammatory and antitumor activity. In this study, we investigated the anticancer effects of phloroglucinol on insulin-like growth factor-1 receptor (IGF-1R) signaling in HT-29 human colon cancer cells. Apoptosis was evaluated using 4',6-diamidino-2-phenylindole (DAPI) staining, which clearly demonstrated cell shrinkage...