Phosphonopropoxymethyl-guanine is the methylene phosphonate analogue of acyclovir. Although not highly active against HSV, 4-38 microM of phosphonopropoxymethyl-guanine has been reported to be active against human and murine cytomegalovirus. Recently we found that cidofovir, when esterified with alkoxyalkyl moieties, showed greatly increased antiviral activity against cytomegalovirus, herpes si...

The development of reusable fire-safe polymers with a prolonged lifetime heralds the switch for transition towards circular economy. In this framework, we report novel phosphonated thermoset which is composed networked phosphonate esters containing both PC and PO bonds. Employing simple one-pot, two-step synthetic methodology, oxirane groups epoxy resin were partially reacted various amounts re...

In this work, ZnCaO2 (zinc oxide-calcium oxide) nanocomposite were synthesized at different temperatures (500-700°C) by sol-gel method based on polymeric network of polyvinyl alcohol (PVA). The synthesized samples were characterized by SEM/EDAX, FT-IR and XRD techniques. It was found that synthesized nanocomposites have 1.62, 2.05 and 13.91%wt of CaO, respectively. The obtained results show tha...

Phosphonoformate (PFA) is an effective antiviral agent that is used clinically in AIDS chemotherapy under the names of Foscarnet and Foscavir.1 Although the primary indication is AIDS-related human cytomegalovirus (HCMV) infection, PFA is also effective against HIV itself. PFA is proposed to act via inhibition of reverse transcriptase in HIV and DNA polymerase in herpes simplex virus (HSV) and ...

In this work, ZnCaO2 (zinc oxide-calcium oxide) nanocomposite were synthesized at different temperatures (500-700°C) by sol-gel method based on polymeric network of polyvinyl alcohol (PVA). The synthesized samples were characterized by SEM/EDAX, FT-IR and XRD techniques. It was found that synthesized nanocomposites have 1.62, 2.05 and 13.91%wt of CaO, respectively. The obtained results show tha...

in this work, zncao2 (zinc oxide-calcium oxide) nanocomposite were synthesized at different temperatures (500-700°c) by sol-gel method based on polymeric network of polyvinyl alcohol (pva). the synthesized samples were characterized by sem/edax, ft-ir and xrd techniques. it was found that synthesized nanocomposites have 1.62, 2.05 and 13.91%wt of cao, respectively. the obtained results show tha...

Eight DO3A-based lanthanide(III) complexes bearing ester protected and unprotected phosphonate groups at variable distances from the macrocyclic moiety have been synthesized and analyzed. The ligands were made by straightforward four-step synthetic procedures and purified with preparative RP-HPLC, after which they were used to prepare gadolinium(III) and europium(III) complexes. Relaxometric ex...

Using three examples it is shown how the metal ion incorporated i n the macrocyclic ring modifies the reactivity of functional groups i n the side chain. The first series includes Cu2+ promoted hydrolysis reactions of a nitrile 2 , of several esters 3-5, of a phosphonate ester 6 and of an amide 7. The mechanism of the hydrolysis of the nitrile and of the phosphonate ester are consistent with an...