Objective(s): Cyclic AMP (adenosine monophosphate) response element-binding protein (CREB) and Brain-derived neurotrophic factor (BDNF) are reported to broadly involve in learning capacity and memory. BDNF exerts its functions via tropomyosin receptor kinase B (TrkB). BDNF transcription is regulated by stimulating CREB phosphorylation. The CREB-TrkB-BDNF pathway is rep...

Chemical phosphorylation of hydrolysate resulting from hydrothermal carbonization chicken feather waste was performed to enhance the amino acids and reduce metal ions content. The aim this research is improve functional properties feathers without impairing nutritional availability thereof with cheapest chemical method by phosphorylation. Phosphorylated can function as animal feed fertilizer. o...

ATCUN (amino terminal Cu(II) and Ni(II) binding) motifs chelate ions strongly. However, the impact of phosphorylation neighboring residues on such complexation has not been elucidated. The copper(II) dissociation constants original phosphorylated peptides from human histatin-1 serum albumin were compared using spectroscopic methods. Phosphorylation markedly weakened binding. Thus, these results...

mitochondrial myopathy, lactic acidosis, and sideroblastic anemia (mlasa) syndrome is a rare autosomal recessive disorder of oxidative phosphorylation and iron metabolism. the association between myopathy and sideroblastic anemia was initially reported in 1974. here we report an 8.5 year old boy with normal cognitive function, suffering from chronic progressive weakness in his lower extremities...

Objective: Coronary heart disease (CHD) is one of the most common diseases. Coronary angiography (CAG) is an important apparatus used to diagnose and treat this disease. Since angiography is performed through exposure to ionizing radiation, it can cause harmful effects induced by double-stranded breaks in DNA which is potentially life-threatening damage. The aim of the present study is to inves...

Phosphorylation has been hypothesized to alter the ability of tau protein bind with microtubules (MT), and pathological level phosphorylation can incorporate formation Paired Helical Filaments (PHF) in affected tau. Study effect on different domains (projection domain, microtubule binding sites N-terminus tail) is important obtain insight about neuropathology. In an earlier study, we have alrea...

Phosphorylation is a reversible, enzyme-controlled posttranslational process affecting approximately one-third of all proteins in eukaryotic cells at any given time. Any deviation the degree and/or site phosphorylation leads to an abnormal conformation proteins, resulting decline or loss their function. Knowledge phosphorylation-related pathways essential for understanding disease pathogenesis ...

Glioma is one of the most common primary brain tumors, and mortality due to this disease second only cardiovascular cerebrovascular diseases. In traditional surgery, it difficult eradicate glioma; often recurrence increases its malignant degree, leading a large number patients killed by disease. It important subjects study pathogenesis explore effective treatment methods. Research on glioma mec...

ABSTRACT The C-terminal of G protein-coupled receptors is now recognized as being important for protein activation and signaling function. To detect the role tail in receptor activation, we used α1b-AR, which has a long 164 amino acids. We constructed intramolecular FRET sensors, was truncated to 10 (∆C-10), 20 (∆C-20), 30 (∆C-30), 50 (∆C-50), 70 (∆C-70), or 90 (∆C-90). mutants ∆C-10, ∆C-20, ∆C...

Protein tyrosine phosphatases (PTPases) regulate the tyrosine phosphorylation of target proteins in‌volved in several biological activities including cell proliferation and transformation. Protein tyrosine phosphatase E (PTPE) contains duplicated PTPase-like domains and a short extracellular region. Us‌ing the fluorescence in situ hybridization method, the gene encoding PTPE (locus symbol Ptpre...