Streptococcal M protein is one of the best characterized anti-phagocytic surface molecules. The protein has a coiled fibrillar structure extending outwards about 600 nm from the streptococcal cell wall. The anti-phagocytic nature of the M protein appears to be related to two properties: ( a ) its ability to bind fibrinogen and the D family of its degradation products, thereby preventing deposit...

Proteins of the same kind in human milk and cow's milk have different properties. Mellander (1947) reports differences in phosphorus content and the amount of carbohydrates of casein and that the casein of cow's milk is more easily digested by proteolytic enzymes in vitro than that of human milk. Kiyosawa, Ryoki & Maeno (1961) observed a marked difference in the solubility of casein and the tur...

Hesperidin nanocrystals was generated by high pressure homogenization. The physicochemical properties of a spray dried hesperidin nanocrystals were investigated including to re-dispersion, crystalline state, kinetic solubility, dissolution velocity. Hesperidin nanosuspension with concentration of 10% (w/v) was dried by a Mini Spray-dryer B-190. Photon correlation spectroscopy (PCS) and laser di...

It has been known since Wilson's discovery (I) that dissociated ceils of Microd~a come together and form aggregates, which by further transformation develop into new sponges. Similar processes were observed in fresh water and in calcareous sponges (2, 3), and in hydroids and alcyonarians (4, S). Recently one of us (6, 7), in studying the behavior of dissociated cells of Microdona, found that th...

brane disease which is a major CauSe Of death Of newborn (premature) infants. However, there are other pathological Appi. physiol. 42,483-491 lung conditions connected with surfactant. Adult respiratory distress syndrome (Lachmann, 1983), alveolar lipoChemosphere 13, 101-105 proteinosis (Claypool et al., 1984), and acute pancreatitis (Idegami et al., 1983) are examples of such conditions. Vario...

The physicochemical properties of bovine prothrombin and of bovine thrombin were previously described in this journal (1, 2). A derivative of bovine prothrombin, autoprothrombin II, has now been obtained in sufficient quality and quantity for study. In this report we describe some of the physicochemical properties of our product, including sedimentation coefficient, diffusion coefficient, intri...

The aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. Few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on Polar surface...