Phytoestrogens are naturally occurring compounds that have similar molecular structure to estrogen hence able exert estrogenic activities by binding receptors (ERs), ERα and ERβ. been reported suppress cancer cell survival growth in various types of cancers including lung cancer, breast prostate cancer. Moreover, phytoestrogens shown inhibit migration invasion targeting multiple pathways. These...

Many commercial laboratory diets have detectable levels of isoflavones (e.g., phytoestrogens such as genistein [GN]) that have weak estrogenic activity both in vitro and in vivo. During validation studies of the uterotrophic bioassay, diet samples from 20 participating laboratories were collected and analyzed for three major phytoestrogens: GN, daidzein (DN), and coumestrol (CM). Soy phytoestro...

The southern white rhinoceros population in captivity has a disappointing reproductive rate and the reason behind this is unknown. On the contrary, the wild population has grown steadily over the last two decades and is still growing. In captivity, white rhinos are given a diet of mainly alfalfa and soy-based products, which contains high concentrations of phytoestrogens. Phytoestrogens are kno...

The majority of breast cancers are oestrogen dependent and in postmenopausal women the supply of oestrogens in breast tissue is derived from the peripheral conversion of circulating androgens. There is, however, a paradox concerning the epidemiology of breast cancer and the dietary intake of phytoestrogens that bind weakly to oestrogen receptors and initiate oestrogen-dependent transcription. I...

Alcoholic beverages contain not only alcohol but also numerous other substances (i.e., congeners) that may contribute to the beverages' physiological effects. Plants used to produce alcoholic beverages contain estrogenlike substances (i.e., phytoestrogens). Observations that men with alcoholic cirrhosis often show testicular failure and symptoms of feminization have suggested that alcoholic bev...

We investigated the estrogenic activity of various environmental pollutants (xenobiotics), in particular the xenoestrogen o,p-DDT, and compared their effects with those of endogenous estrogens, phytoestrogens, and mycoestrogens on estrogen receptor binding capacity, induction of estrogen end products, and activation of cell proliferation in estrogen-sensitive human breast cancer cells in monola...

There has been substantial interest in phytoestrogens, because of their potential effect in reducing cancer and heart disease risk. Measuring concentrations of phytoestrogens in urine is an alternative method for conducting epidemiological studies. Our objective was to evaluate the urinary excretion of phytoestrogens as biomarkers for dietary phytoestrogen intake in Mexican women. Participants ...

The intake, as well as serum and urinary concentrations, of phytoestrogens is high in countries where incidence of prostate cancer is low, suggesting a chemopreventive role for phytoestrogens. Their significance could be explained by the ability to antagonize the action of more potent endogenous estrogens in initiation or promotion of tumor formation. We have studied estrogenicity and antiestro...

Polychlorinated biphenyls (PCBs) and phytoestrogens were found to affect contractions of bovine uterus. Prostaglandins (PG) F2α and E2 are also involved in the uterine contractility. Hence the aim of these studies was to investigate the effect of PCBs and some phytoestrogens on PG secretion from endometrial cells obtained on days 1–5 of the oestrous cycle. Cells were incubated in aerated atmosp...

Phytoestrogens Hepatocellular carcinoma Chemoprevention Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver and the third leading cause of cancer mortality worldwide. Statistically liver cancer is the fifth most common cancer in men and the 7th most common cancer in women. The major common risk factors for hepatocellular are hepatitis B (HBV) and hepatitis C vi...