measuring and comparing grip and pinch strengths with their normative data is a valid method to detect intensity of the numerous damages of hand. this research was carried out with the aim of establishing normative data of grip strength and three types of pinch strengths (tip, key and palmar) in healthy iranian adults.in this cross-sectional study, the study population was formed of 1008 people...

PROBLEM Translational research aims to move scientific discoveries across the biomedical spectrum from the laboratory to humans, and to ultimately transform clinical practice and public health policies. Despite efforts to accelerate translational research through national initiatives, several major hurdles remain. APPROACH The authors created the Pitt Innovation Challenge (PInCh) as an incent...

Common methods to design heat exchanger networks (HENs) by pinch technology usually need an evolutionary step to reduce the number of heat transfer units. This step <span style="font-size: 10pt; color:...

PINCH, integrin-linked kinase (ILK) and Ras suppressor-1 (RSU-1) are molecular scaffolding proteins that form a physical complex downstream of integrins, and have overlapping roles in cellular adhesion. In Drosophila, PINCH and ILK colocalize in cells and have indistinguishable functions in maintaining wing adhesion and integrin to actin linkage in the muscle. We sought to determine whether the...

results grip strength and tip and palmer pinch strength in dominant side were statistically greater than them in nondominant side (p < 0.05). there were significant associations between grip strength and height (r = 0.33, p < 0.001), body mass (r = 0.50, p < 0.001), bmi (r = 0.37, p < 0.001), muscle mass of upper extremity (r = 0.56, p < 0.001), fat free mass (r = 0.57, p < 0.001), fat mass (r ...

Particularly interesting Cys-His-rich protein (PINCH) has several biological functions in cancer development, invasion and metastasis in malignant cells, and the expression of PINCH is upregulated in several cancer types, including breast cancer, gastric adenocarcinoma and rectal cancer. However, the contribution of PINCH to human cerebral aneurysms remains largely unknown. Therefore, the signi...

PINCH-1 is a LIM-only domain protein that forms a ternary complex with integrin-linked kinase (ILK) and parvin (to form the IPP complex) downstream of integrins. Here, we demonstrate that PINCH-1 (also known as Lims1) gene ablation in the epidermis of mice caused epidermal detachment from the basement membrane, epidermal hyperthickening and progressive hair loss. PINCH-1-deficient keratinocytes...