We report here in vitro and in vivo antitumour activity study of a series of 1,3-dimethyl-N substituted acridone derivatives. All the molecules have been designed on the basis of the presence of specific recognition patterns consisting of electron donor, carbons. Chloro groups with precise spatial separation and structural features (lipophilicity, positive charge at neutral pH and presence of a...

the biodegradation of secondary amines is particularly important due to their propensity for conversion either chemically or microbiologically to n-nitrosamines which are potent carcinogens. in this research, a weak gram-positive organism was isolated from river and identified as mycobacterium. this mycobacterium grows slowly and effectively utilizes piperazine as the sole source of organic, ca...

Piperazine is widely used as an intermediate in the manufacture of insecticides, rubber chemicals, corrosion inhibitors, and urethane. In this study, a highly effective piperazine-degrading bacteria strain, TOH, was isolated from the acclimated activated sludge of a pharmaceutical plant. This strain, identified as Paracoccus sp., utilises piperazine as the sole source of carbon, nitrogen and en...

BACKGROUND Piperazine is a secondary heterocyclic amine that may give rise to occupational asthma of uncertain mechanism. METHODS We report on a 42-year-old woman, a process operator in a chemical factory, who developed work-related symptoms of rhinitis and asthma upon exposure to piperazine citrate. She remained symptom free during holidays and days off work. RESULTS Skin prick test with p...

1. The action of piperazine on mammalian smooth, cardiac and skeletal muscles has been studied.2. Piperazine increased tone and produced a dose dependent contraction of isolated smooth muscle, which was antagonized by atropine.3. With cardiac muscle, piperazine depressed both the rate and force of contraction and was antagonized by atropine. At higher concentrations, a non-specific depression o...

The biodegradation of secondary amines is particularly important due to their propensity for conversion either chemically or microbiologically to N-nitrosamines which are potent carcinogens. In this research, a weak Gram-positive organism was isolated from river and identified as Mycobacterium. This Mycobacterium grows slowly and effectively utilizes piperazine as the sole source of organic, c...

in this study oxyuris and ascaris infections alone or in combination were treated with vanapar a combination of pyrvinium pamoate and piperazine administered in two successive daily doses. this resulted in a 100% cure rate of oxyuriasis as well as a substantial reduction in ova count for ascaris, amounting to 97% success rate in achieving ova count reduction. vanapar was highly effective for th...