The potential of the paired Ig-like receptors of activating (PIR-A) and inhibitory (PIR-B) types for modifying an IgE antibody-mediated allergic response was evaluated in mouse bone marrow-derived mast cells. Although mast cells produced both PIR-A and PIR-B, PIR-B was found to be preferentially expressed on the cell surface, where it was constitutively tyrosine phosphorylated and associated wi...

Paired immunoglobulin-like receptor (PIR)-A and PIR-B possess similar ectodomains with six immunoglobulin-like loops, but have distinct transmembrane and cytoplasmic domains. PIR-B bears immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in its cytoplasmic domain that recruit Src homology (SH)2 domain-containing tyrosine phosphatases SHP-1 and SHP-2, leading to inhibition of B and ...

A Private Information Retrieval (PIR) protocol enables a user to retrieve a data item from a database while hiding the identity of the item being retrieved. In a t-private, k-server PIR protocol the database is replicated among k servers, and the user’s privacy is protected from any collusion of up to t servers. The main cost-measure of such protocols is the communication complexity of retrievi...

In e-commerce, the protection of user privacy from a server was not considered feasible until the private information retrieval (PIR) problem was stated recently. A PIR protocol allows a user to retrieve a record from a database while hiding the identity of the record from a database server. We explain a motivation for PIR by demonstrating ecommerce examples, where only PIR techniques help. All...

Let A and B denote cryptographic primitives. A (k,m)robust A-to-B combiner is a construction, which takes m implementations of primitive A as input, and yields an implementation of primitive B, which is guaranteed to be secure as long as at least k input implementations are secure. The main motivation for such constructions is the tolerance against wrong assumptions on which the security of imp...

A Single-Database Private Information Retrieval (PIR) is a protocol that allows a user to privately retrieve from a database an entry with as small as possible communication complexity. We call a PIR protocol non-trivial if its total communication is strictly less than the size of the database. Non-trivial PIR is an important cryptographic primitive with many applications. Thus, understanding w...

Lung cancer is the leading cause of cancer-related death worldwide. Although advanced drugs have benefitted patients, therapeutic success has largely been hampered because of rapid development of resistance. Here we report that PIWI-interacting RNA likes (piR-Ls), a novel type of functional sncRNAs, play key roles in chemoresistance to cisplatin (CDDP)-based chemotherapy in lung squamous cell c...

Direct interaction between T-suppressor and dendritic cells (DCs) results in DC tolerance by inducing upregulation of immunoglobulin-like transcript (ILT) 3 and ILT4. DCs were treated with a lentiviral vector containing paired immunoglobulin-like B gene (PIR-B) DCs and the effect of PIR-B-DCs on graft-versus-host disease (GVHD) was analyzed after allogeneic bone marrow (BM) transplantation (BMT...

Consider the problem of private information retrieval (PIR) over a distributed storage system where M records are stored across N servers by using an [N,K] MDS code. For simplicity, this problem is usually referred as the coded-PIR problem. The capacity of coded-PIR with privacy against any individual server was determined by Banawan and Ulukus in 2016, i.e., CC-PIR = (1 + K N + · · · + K M−1 N...

The Protein Information Resource (PIR) is an integrated public resource of protein informatics that supports genomic and proteomic research and scientific discovery. PIR maintains the Protein Sequence Database (PSD), an annotated protein database containing over 283 000 sequences covering the entire taxonomic range. Family classification is used for sensitive identification, consistent annotati...