BACKGROUND Plague, a zoonosis caused by Yersinia pestis, is found in Asia and the Americas, but predominantly in Africa, with the island of Madagascar reporting almost one third of human cases worldwide. Plague's occurrence is affected by local climate factors which in turn are influenced by large-scale climate phenomena such as the El Niño Southern Oscillation (ENSO). The effects of ENSO on re...

tentative synthesis of the results of the researches on plague initiated in 1941 with georges blanc in morocco, carried on in the persian kurdistan since 1947 then in india, in syria, in turkey, in irak and in java. new acquisitions on the epidemization of human bubo-septicemic plague, discovery of the mode of spread of the rural plague, of the reasons of the seasonal nature of the disease unde...

Plague in Brazil is poorly known and now rarely seen, so studies of its ecology are difficult. We used ecological niche models of historical (1966-present) records of human plague cases across northeastern Brazil to assess hypotheses regarding environmental correlates of plague occurrences across the region. Results indicate that the apparently focal distribution of plague in northeastern Brazi...

This anomaly, though already known has received little attention;1 neither Ziegler nor Gottfried, writing in 1969 and 1983 respectively, questioned the bubonic plague assumption.2 Shrewsbury’s detailed history of bubonic plague in the British Isles in 1971 did little to explore the problems of plague in a cold temperate climate.3 Indeed, so fixed was he upon the rat-flea plague model that he di...

Yersinia pestis, the causative agent of plague, is an emerging threat as a means of bioterrorism. Accordingly, the Working Group on Civilian Biodefense, as well as the Centers for Disease Control and Prevention, has specified Y. pestis as a prime candidate for use in bioterrorism. As the threat of bioterrorism increases, so does the need for an effective vaccine against this potential agent. Ex...

Predators play important roles in the ecology, epidemiology, and surveillance of plague in the United States. Most predators are accidental hosts of plague and, with the possible exception of grasshopper mice (Onychomys spp.), are not important sources of infection for feeding fleas. However, predators undoubtedly do play an important role in the natural cycle of plague by transporting infected...

Yersinia pestis, the causative organism of the plague, has played an important role in shaping human history. Plague is an illness that may manifest in bubonic, pneumonic, or septicemic form. Natural outbreaks devastated entire populations in medieval times and an estimated 200 million humans were killed by plague throughout history. The organism can still be found today throughout the world, i...

HE Chinese winter of 1910-1911 was one of death and discontent: an epidemic of pneumonic plague—the greatest since the Black Death of the fourteenth century—scourged China's three Eastern Provinces (Manchuria), and famine afflicted the Central Provinces. The Manchurian plague claimed some fifty thousand lives in four months, and the famine took thousands more. Not all the hungry died, but no on...

In September 1994, in response to a reported epidemic of plague in India, the Centers for Disease Control and Prevention (CDC) enhanced surveillance in the United States for imported pneumonic plague. Plague information materials were rapidly developed and distributed to U.S. public health officials by electronic mail, facsimile, and expedited publication. Information was also provided to medic...