in the present study, variation among different bacterial strains was observed in the plaques of tobacco chewers (tc) as compared to those from normal persons (non tobacco chewers) (ntc). bacterial strain j1 (dominant in the plaques of ntc) did not initiate the process of adhesion (biofilm formation) until it appeared to have reached a required population density necessary for the production of...

Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...

Abstract The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis started near plaques in both AD mouse models and samples. However, endothelial cells express molecular signature of non-productive (NPA) accumulate, plaques, a tip cell marker IB4 reactive vascular a...

Senile plaques and cerebrovascular amyloidosis are major histopathological lesions in the brains of aged dogs. Different types of amyloid beta protein (A beta) positive plaques are known: diffuse ones and neuritic plaques. Diffuse plaques may contain membrane-bound A beta and/or small amounts of amyloid fibrils. Neuritic plaques are cored plaques with clusters of amyloid fibrils and degeneratin...

OBJECTIVES Mechanical and structural characteristics of vulnerable plaques were evaluated using coronary angioscopy and intravascular ultrasound. BACKGROUND Mechanical stress and composition of plaques play an important role in plaque disruption. METHODS Thirty-eight lesions in 38 patients were examined pre-interventionally. The plaques were classified as either yellow or white using corona...