parkinson's disease is a degenerative disorder of the central nervous system. the motor symptoms of parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. homocysteine (hcy) is a non-protein amino acid. it is a homologue of the amino acid cysteine. the elevated levels of homocysteine in pl...

Dietary protein digestion and amino acid absorption kinetics determine the post-prandial muscle protein synthetic response. Body position may affect gastrointestinal function and modulate the post-prandial rise in plasma amino acid availability. We aimed to assess the impact of body position on gastric emptying rate and the post-prandial rise in plasma amino acid concentrations following ingest...

Endogenous and exogenous stimulation of the pancreas was studied to determine whether changes in protein output could be linked to decreased total plasma amino acid concentrations. In fasted rats, diversion of pancreatic juice resulted in a transient increase in protein output and a linked fall in total plasma amino acid. In fed animals, however, diversion of juice did not result in any change ...

Introduction: Drugs are mainly delivered to the target tissues by plasma proteins, such as human serum albumin, in the human body. Practical information about the thermodynamic parameters of drugs and their stability can be obtained using simulation methods, such as molecular docking. Material & Methods: This study, investigated the molecular docking of human serum albumin with fluorouracil an...

Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of essential amino acids with non-essential amino acids and the transfer of amino groups from oxidised amino acids to amino acid biosynthesis. This homeostatic condition is maintained through an active mTORC1 complex. Under ...

an experiment was conducted to reevaluate the digestible lysine requirement of arian male broilers by comparing the performance of chicks fed different levels of cottonseed meal (csm) on a total amino acid (aa) versus a digestible aa basis. four hundred and thirty two (432) arian male broiler chicks were allotted to 18 treatments with four repli-cates of six chicks each in a completely randomiz...

To clarify the role of skeletal muscle in the regulation of plasma amino acid levels, we investigated the response of skeletal muscle to changes in plasma amino acid levels using the perfusion technique of rat hindquarters. The hindquarters of overnight-fasted rats were perfused with a medium containing no amino acids (0 X) and amino acids with plasma levels simulating normal (1 X) or 5 times t...

Amino acid mixtures corresponding to either casein or egg yolk protein when fed to rabits ina low fat, cholesterol-free semipurified diet, produced the same degree of hypercholesterolemia as the proteins themselves. Amino acid mixtures corresponding to soy protein isolate or sunflower protein gave low plasma cholesterol levels, but not as low as those obtained with the intact proteins. Experime...

The amino acid composition of purified human plasma prothrombin was determined by ion exchange chromatography. In some cases, the carbohydrate composition was also estimated. Seven preparations, isolated in two different laboratories and finally purified by two different methods, were studied. Within experimental error, all the preparations had the same amino acid composition, which was as foll...

PPARalpha agonists have been characterized largely in terms of their effects on lipids and glucose metabolism, whereas little has been reported about effects on amino acid metabolism. We studied responses to the PPARalpha agonist WY 14,643 (30 micromol x kg(-1) x day(-1) for 4 wk) in rats fed a saturated fat diet. Plasma and urine were analyzed with proton NMR. Plasma amino acids were measured ...