Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

Metabolomics has been used as a powerful tool for the analysis and quality assessment of the natural product (NP)-derived medicines. It is increasingly being used in the quality control and standardization of NP-derived medicines because they are composed of hundreds of natural compounds. The most common techniques that are used in metabolomics consist of NMR, GC-MS, and LC-MS in combination wi...

Background: Considering the increasing number of patients with hemophilia and infrastructure requirements for a comprehensive approach, development of a recombinant factor has become a milestone. The objective of this study was to assess the safety, efficacy and non inferiority of Safacto (Recombinant factor VIII) compared with plasma-derived factor in the treatment of hemophilia A. Methods: 10 ...

OBJECTIVE To examine the opinions of Libyan doctors regarding the quality of drug information provided by pharmaceutical company representatives (PCRs) during detailing visits. METHOD An anonymous survey was conducted among 1,000 doctors from selected institutes in Tripoli, Benghazi and Sebha. Doctors were asked questions regarding the quality of information provided during drug-detailing vis...

introduction: silymarine extract is currently prescribed by some physicians for treatment of fatty liver disease. in the present study, the effect of administration of tablet containing silymarine extract on plasma homocysteine (hcy), folate, vitamin b12 and liver enzymes activity in non-alcoholic steatohepatitis (nash) was investigated. materials and methods: seventy-four patients (40 female a...

medicines constitute a substantial proportion of out-of-pocket (oop) expenses in indian households. in order to address this issue, the government of india launched the jan aushadhi (medicine for the masses) scheme (jas) to provide cheap generic medicines to the patients (http://janaushadhi.gov.in/about_jan_aushadhi.html). these medicines are provided through the jan aushadhi stores established...

a healthcare system has been the most important priority for all governments worldwide. biotechnology products have affected the promotion of health care over the last thirty years. during the last several decades, iran has achieved significant success in extending healthcare to the rural areas and in reducing the rates of infant mortality and increasing population growth. biomedical technology...