• TRALI may be induced by antibodies to HLA or HNA antigens or lipids, which accumulate during storage. • Prestorage experimental filtration of RBCs removes HLA and HNA antibodies, decreases lipid priming activity, and mitigates TRALI in an animal model. Transfusion-related acute lung injury (TRALI) remains a significant cause of transfusionrelated mortality with red cell transfusion. We hypoth...

The kidneys filter the plasma in special filtration units-glomeruli-and thereby excrete low-molecular-weight waste products into the urine. The mechanisms of glomerular filtration have been a matter of controversy for several decades, but recent data have revealed new details about the molecular nature of the filter and have demonstrated a central role for the podocyte slit diaphragm in the fil...

Glomerular filtration rate was measured from the plasma disappearance curve after a single injection of sodium (125)I-diatrizoate. A therapeutic dose of aspirin in 13 subjects produced a mean fall in glomerular filtration rate of 10.5%.

BACKGROUND AND OBJECTIVES This study aimed at evaluating acute radiological contrast effects in fluid restriction situations, observing renal and cardiovascular effects after intra-arterial injection of high osmolarity radiological contrast. METHODS Participated in this study 16 dogs anesthetized with sodium thiopental (15 mg.kg-1) and fentanyl (0.03 mL.kg-1), followed by continuous infusion ...

Changes in glomerular filtration rate and effective renal plasma flow following a protein meal were measured in seven patients with essential hypertension on no treatment and after 6 weeks' treatment with nifedipine and mefruside. Glomerular filtration rate and effective renal plasma flow increased significantly following a protein meal in patients on no treatment (P less than 0.01 and P less t...

conclusions: these findings suggested that plasma adpn level is inversely associated with gfr and directly correlate with hdl-cholesterol and inversely with some, but not all metabolic factors of ckd patients who were not undergone dialysis. results: plasma adpn level was significantly higher in ckd patients than control group (p = 0.04). it was directly correlated with hdl-cholesterol (r = 0.5...

The study evaluated the quality of plasma obtained after whole-blood filtration with four different polyester filters and one polyurethane filter. The activities of coagulation factors and proteinase inhibitors were not or only negligibly affected by filtration, in all experiments. Filtration did not increase markers of clotting and fibrinolysis. Only a strong neutrophil and complement activati...

The mechanism of glomerular ultrafiltration in normal kidneys or after renal injury is reviewed. The role of increased glomerular plasma flow in mediating increases of nephron filtration rate is evidenced under experimental conditions resulting in filtration pressure disequilibrium along glomerular capillaries. The increase of nephron filtration in hypertrophied kidneys appears to be due mainly...

Lysolecithin comprises 9.6 and 21.5% of the phospholipids of the plasma of man and rat, respectively. Ultracentrifugal and gel filtration studies showed that the major portion of the lysolecithin is not found together with the other phospholipids in the plasma lipoproteins. By zone electrophoresis, gel filtration, and ammonium sulfate fractionation, it was found that lysolecithin was consistent...

Abnormal renovascular resistance and glomerular filtration rate are characteristic of established hypertension and may also be involved in its pathogenesis. To determine renal and body fluid correlates of the predisposition to high blood pressure, we examined 100 healthy young adults with high or low blood pressure. Within each group, half had parents with high blood pressures, and half had par...