This paper describes a paper-based microfluidic device that measures two enzymatic markers of liver function (alkaline phosphatase, ALP, and aspartate aminotransferase, AST) and total serum protein. A device consists of four components: (i) a top plastic sheet, (ii) a filter membrane, (iii) a patterned paper chip containing the reagents necessary for analysis, and (iv) a bottom plastic sheet. T...

fabrication of ultrafine grained materials by imposing severe plastic deformation for improvement of mechanical and physical properties of metals has been the focus of many researches over the past few years. in this process, a sheet is subjected to repetitive shear deformation conditions by utilizing asymmetrically grooved and flat dies through alternate pressing. in this study, a 2mm thick co...

in this work, an inverse finite element formulation was modified for considering material anisotropy in obtaining blank shape and forming severity of deep drawn orthotropic parts. in this procedure, geometry of final part and thickness of initial blank sheet were known. after applying ideal forming formulations between material points of initial blank and final shape, an equation system was obt...

The integration of stem cell technology and cell sheet engineering improved the potential use of cell sheet products in regenerative medicine. This review will discuss the use of mesenchymal stem cells (MSCs) in cell sheet-based tissue engineering. Besides their adhesiveness to plastic surfaces and their extensive differentiation potential in vitro, MSCs are easily accessible, expandable in vit...

Temporal and spatial characteristics of serrated plastic flow or the so-called Portevin-Le Chatelier (PLC) deformation bands in a commercial Al-2.5%Mg sheet metal due to dynamic strain aging effects were investigated experimentally under quasi-static uniaxial tension. It was found that the thickness and width of test coupons, applied loading conditions (machine stiffness and crosshead speed), a...

Although we state that "the inability of the upper cell surface to support spreading may be a general phenomenon ," we point out in the text (reference 4, p. 219) that "we limit our conclusions only to the cell types used in this study and only to in vitro conditions." In fact, we cite one case where this may not apply. In his letter, Dr. Prop cites several cases where cells in culture are appa...