A series of novel N-[2-(substituted phenyl)-5-methyl-4-oxo-1,3-thiazolidin-3-yl]benzamides (4a-g) were synthesized, structurally confirmed by elemental analysis, IR, H NMR and MS spectral analysis, further evaluated for their anti-HIV activity and cytotoxicity in MT-4 cells infected with wildtype HIV-1 strain IIIB and HIV-2 strain ROD in comparison with nevirapine (NVP), azidothymidine (AZT), d...

Methods In vitro micro-co-culture was employed for virus isolation followed by drug susceptibility assays to determine resistance to Azidothymidine (AZT) and Lamivudine (3TC). Jatropha curcasleaves were extracted using Soxhlet apparatus. Methanolic (ME) and aqueous (AE) extracts were chosen for further study. Secondary metabolites were detected by High-Performance Thin Laye rChromatography and ...

Platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. Cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. The nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. We exa...

A series of novel 2-[(substituted phenyl/heteroaryl)imino]-3-phenyl-1,3-thiazolidin-4-ones (4a-g) were synthesized, structurally confirmed by elemental analysis, IR, H NMR, MS spectral analysis and further evaluated for their anti-HIV activity and cytotoxicity in MT-4 cell cultures infected with wild-type HIV-1 strain IIIB and HIV-2 strain ROD in comparison with azidothymidine (AZT) and dideoxy...

A single-step amino acid-catalyzed diastereoselective three-component synthesis of optically pure highly functionalized spiro[5,5]undecane-1,5,9-triones preferentially over the four stereoisomers was accomplished in very good yields with >99% ee/de. Preliminary cell culture-based in vivo screening on these molecules revealed that cis-1aca and cis-1jca are better lead compounds for HIV-1 treatme...

BACKGROUND an anticipatory decision document records a person's wishes regarding medical treatment at a time when they have capacity to make choices, to be enacted when this capacity is lost. In England and Wales an advance decision to refuse treatment (ADRT, or advance decision), a legally binding document, is currently rarely used. A disparity is suggested to exist between physicians' support...

The goal of this work is the separation and recovery of platinum and palladium from spent catalyst. The recovery consisted of separating the maximum amount of platinum and palladium from catalysts and changing them into usable forms. The petroleum and petrochemical units use Pt and Pd catalyst for reactions such as reforming and hydrogenation. Because these materials contain valuable metals...