نتایج جستجو برای: plga nanosphere

تعداد نتایج: 4541  

2007
Z. G. Tang J. A. Hunt

Ratio blends of PLGA/PCL: (0:10), (1:9), (2:8), (3:7), (4:6), (5:5), (6:4), (7:3), (8:2), (9:1), and (10:0) were spin-coated to produce thin films; surface topographies were determined using interferometric microscopy. It was demonstrated that micro-wells of a defined size (150 mm) were present in all PCL dominant PLGA/PCL systems. Stratification of PLGA with PCL enabled the formation of that s...

Journal: :Journal of tissue engineering and regenerative medicine 2016
Hongbing Liao Rosa P Félix Lanao Jeroen J J P van den Beucken Nuo Zhou Sanne K Both Joop G C Wolke John A Jansen

The aim of this study was to evaluate the effect of PLGA microsphere dimensions on bone formation after injection of calcium phosphate cement (CPC)/PLGA in a guinea pig tibial intramedullarly model. To this end, injectable CPC/PLGA formulations were prepared using PLGA microspheres with either a small (~25 µm) or large (~100 µm) diameter, which were incorporated at a 20:80 ratio (wt%) within ap...

Journal: :Urology journal 2014
Farzaneh Sharifiaghdas Mohammad Naji Reza Sarhangnejad Sareh Rajabi-Zeleti Hamid Mirzadeh Mojgan Zandi Mahdi Saeed

PURPOSE To compare human urothelial and smooth muscle cells attachment and proliferation using three different matrices; poly lactic-co-glycolic acid (PLGA), PLGA/collagen and human amniotic membrane (hAM). MATERIALS AND METHODS Human urothelial and smooth muscle cells were cultured and examined for expression of urothelium (pancytokeratin and uroplakin III) and smooth muscle cells [desmin an...

2010
Meltem ÇETİN Yücel KADIOĞLU

This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-coglycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was perform...

Journal: :Investigative ophthalmology & visual science 2017
Evan A Thackaberry Cindy Farman Fiona Zhong Florence Lorget Karin Staflin Angelique Cercillieux Paul E Miller Chris Schuetz Debby Chang Amin Famili Ann L Daugherty Karthik Rajagopal Vladimir Bantseev

Purpose Poly(lactic-co-glycolic) acid (PLGA) inserts have been successfully developed for the treatment of posterior eye disease as a means of reducing injection frequency of intravitreally administered therapeutics. PLGA microspheres are also of interest for the delivery of intravitreal drugs, since they offer the advantage of being easily injected without surgical procedures or large injector...

Journal: :Bioconjugate chemistry 2007
Xue-Qing Zhang Janjira Intra Aliasger K Salem

We report on the preparation and characterization of poly(D, L-lactide-co-glycolide) (PLGA) microparticles with surface-conjugated polyamidoamine (PAMAM) dendrimers of varying generations. The buffering capacity and zeta-potential of the PLGA PAMAM microparticles increased with increasing generation level of the PAMAM dendrimer conjugated. Conjugation of the PAMAM dendrimer to the surface of th...

2018
Luping Du Zhengyu Yu Fengjiao Pang Xiangwei Xu Aihua Mao Wanzhe Yuan Kongwang He Bin Li

Efficient delivery of antigens through oral immunization is a first and critical step for successful induction of mucosal immunity, which can provide protection against pathogens invading the mucosa. Membranous/microfold cells (M cells) within the mucosa can transcytose internalized antigen without degradation and thus play an important role in initiating antigen-specific mucosal immune respons...

اصغری جعفر آبادی, محمد, امامقلی, عسگر, حرفه دوست, غلامرضا, ذوالفقاری, داود, صدرایی, سید همایون, صدری, مینو, کاکا, غلامرضا,

Background and Objective: Poly D,L-lactic-co-glycolic acid (PLGA) is known as biodegradable and biocompatible polymer. These polymers have recently received much attention in tissue engineering. The aim of this study was to investigate the biological behavior of the bone marrow stromal cells (BMSCs) in culturing with PLGA nanofibers coated with poly-L-lysine or gelatin. Materials and Methods: I...

Journal: :Journal of drug targeting 2011
Janjira Intra Aliasger K Salem

Poly(lactide-co-glycolide) (PLGA) microparticles have significant potential for sustained delivery of plasmid DNA (pDNA). However, unmodified PLGA microparticles have poor transfection efficiencies. In this study, we use several approaches to enhance the transfection efficiencies of PLGA microparticles in a HepG2 liver cell line. Polyethylenimine (PEI) is used to condense the pDNA prior to load...

Journal: :Journal of pharmaceutical sciences 2010
Janjira Intra Aliasger K Salem

We report, for the first time, on the preparation, characterization and in vitro testing of poly(D,L-lactide-co-glycolide) (PLGA) microparticles loaded with polyamidoamine (PAMAM)-plasmid DNA (pDNA) dendriplexes. Loading of pDNA into the PLGA microparticles increased by 150% when pDNA was first complexed with PAMAM dendrimers relative to loading of pDNA alone. Scanning electron microscopy (SEM)...

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