Exopolymer-producing bacteria can be used to modify soil profiles for enhanced oil recovery or bioremediation. Understanding the mechanisms associated with biomass plug development and propagation is needed for successful application of this technology. These mechanisms were determined from packed-bed and micromodel experiments that simulate plugging in porous media. Leuconostoc mesenteroides w...

This study presents the development of a plug flow crystallization (PFC) platform consisting of a vortex mixer combined with a tubular reactor. Process analytical technologies (FBRM, PVM, FT-IR) were applied in-situ in order to characterize and optimize crystallizations via the use of novel flow cells. In addition to this a new calibration free method for concentration monitoring was successful...

A mathematical model for the prediction of internal recirculation of complex impinging stream reactors has been presented. The model constitutes a repetition of a series of ideal plug flow reactors and CSTR reactors with recirculation. The simplicity of the repeating motif allows for the derivation of an algebraic relation of the whole system using the Laplace transform. An impinging stream...

Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today's crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in solution via a tubular crystallizer that facilitates rapid temperature cycling. Controlled crystal growth, dissolution, and secondary nucleation allow a precise co...

[1] A generalized constitutive equation for bubbly liquids is presented which successfully reproduces the expected viscosity response for both steady flows with varying capillary number Ca (a measure of the bubble deformation) and unsteady flows with varying dynamic capillary number Cd (a measure of the steadiness of the flow) previously given in separate studies. The constitutive equation is g...

Crystallization processes in the pharmaceutical industry are usually designed to obtain crystals with controlled size, shape, purity, and polymorphic form. Knowledge of the process conditions required to fabricate crystals with controlled characteristics is critical during process development. In this work, continuous crystallization of Ketoconazole, Flufenamic Acid, and L-Glutamic Acid in a no...

In this paper we examine the effect of mild stenosis on blood flow, in an irregular axisymmetric artery with oscillating pressure gradient. The Herschel-Bulkley fluid model has been utilized for this study. The combined influence of an asymmetric shape and surface irregularities of constriction has been explored in this computational study. An extensive quantitative analysis has been performed ...