The present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 m...

Rats trained on a nonmatching-to-turn rule revealed that egocentric working memory is readily disrupted, hard to use, and transient. In Experiment 1, rats failed to acquire the rule in a plus-maze. Experiment 2 used 2 different plus-mazes to remove any intramaze cues. Task acquisition occurred only when rats could use direction cues (i.e., nonegocentric cues). In Experiments 3 and 4, a J maze w...

The influence of ApoE gene deletion on the anxiety state has not been previously investigated. The elevated plus maze was used in this study to determine differences in anxiety-related behavior between apoE-deficient and wild type C57BL/6 mice. The apoE-deficient mice demonstrated less anxiety on the elevated plus maze by spending more time in the open arms of the elevated plus maze compared to...

The present study evaluated the correlation between the behavior of mice in the forced swimming test (FST) and in the elevated plus-maze (PM). The effect of the order of the experiments, i.e., the influence of the first test (FST or PM) on mouse behavior in the second test (PM or FST, respectively) was compared to handled animals (HAND). The execution of FST one week before the plus-maze (FST-P...

The effects of kindling of the right anterior medial amygdala of Wistar rats was studied. Kindling lastingly increased anxiety (decreased open-arm exploration) in the elevated plus-maze 1 week after the last kindled seizure, replicating previous findings. Changes in anxiety were independent of changes in exploration or activity in either the plus-maze or hole board. A new finding is the depende...

This article reviews reported results about the effects of drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MEDLINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From th...

The present study was undertaken to investigate the beneficial effects of Atorvastatin and Simvastatin in cognitive dysfunctions of rats. Alprazolam, Scopolamine and high fat diet (HFD) induced amnesia served as interoceptive memory models where as, Water-maze and Elevated plus-maze served as exteroceptive models. A total of 38 groups of rats were used in this investigation. Escape latency time...