PURPOSE To determine whether patients with isolated primary open-angle glaucoma (POAG) have evidence of chromosomal copy number alterations. METHODS Twenty-seven Caucasian and African-American POAG patients and 12 ethnically matched controls were carefully screened for possible glaucoma and tested for chromosomal copy number alterations using high resolution array comparative genomic hybridiz...

We studied the prevalence of migraine in low-tension glaucoma (LTG) and primary open-angle glaucoma (POAG). Seventy seven Japanese patients with LTG, 73 with POAG, and 75 normal subjects were randomly selected and tested with a headache questionnaire. The prevalence of headache with or without typical migrainous features (unilateral headache or ocular pain, nausea, vomiting, and visual disturba...

PURPOSE The current study was undertaken to investigate whether glaucoma affects the sleep quality and whether there is any difference between patients with primary glaucoma (primary open angle glaucoma, POAG and primary angle-closure glaucoma, PACG) and healthy subjects, using a validated self-rated questionnaire, the Pittsburgh Sleep Quality Index (PSQI). METHODS The sleep quality of patien...

BACKGROUND Primary open angle glaucoma (POAG) is considered to be a leading cause of irreversible blindness worldwide. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) have been extensively studied as POAG risk factors. Recently, several single-nucleotide polymorphisms (SNPs) for MMPs and TIMPs encoding genes have been reported in POAG patients. The aim of this study was to investi...

PURPOSE To determine the prevalence of glaucoma and risk factors for primary open-angle glaucoma in a rural population of southern India. DESIGN A population-based cross-sectional study. PARTICIPANTS A total of 5150 subjects aged 40 years and older from 50 clusters representative of three southern districts of Tamil Nadu in southern India. METHODS All participants had a comprehensive eye ...

Background: Glaucoma is one of the most typical causes irreversible visual impairment in globe, Primary open-angle glaucoma (POAG) common subtype disease and can impact quality life by affecting field even if patient unaware his diagnosis. Aim work: To measure peripapillary choroidal thickness (PCT) POAG patients to assess correlation between degree condition using enhanced depth imaging optica...

This study aims to assess the effectiveness of ganglion cell-inner plexiform layer (GCIPL) measurements in preperimetric glaucoma (PPG) and primary open angle glaucoma (POAG). GCIPL and retinal nerve fiber layer (RNFL) thickness were measured in PPG, POAG, and control groups. The data obtained from these three groups were compared with analysis of variance and post hoc Tukey test. Average GCIPL...

Objective: The objective of this study was to compare the safety BAK-preserved latanoprost versus travoprost BAK-free ophthalmic solution in primary open-angle glaucoma (POAG). Methods: Prospective, open-labeled, and randomized comparative conducted tertiary care hospital. Forty patients were enrolled divided into 20 each group: Group A topical (0.005%) with BAK B (0.004%). Safety assessment do...

OBJECTIVE Primary open angle glaucoma (POAG) is the most common type of glaucoma in Africa. We carried out a study to determine the clinical presentation pattern of patients with primary open angle glaucoma (POAG) at a tertiary hospital in Malawi. DESIGN A cross-sectional study. SETTING Lions Sight First Eye Hospital-a major referral and teaching state eye hospital in Blantyre, Malawi. SU...

PURPOSE To determine whether or not there is an association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with disease in cohorts of primary open-angle glaucoma (POAG) and primary closed-angle glaucoma (PCAG) from Pakistan. METHODS This was a prospective study consisting of 150 patients (90 POAG and 60 PCAG) and 70 control subjects. Genomic DNA was extracted from leuko...