The purpose of this study is to develop and characterize the nature of a solid dispersion system of nifedipine in a polymer matrix consisting of PVP K30 and poloxamer 407. Dispersions consist of drug, polymeric carrier and surfactant carrier. Binary solid dispersions consisting of nifedipine and PVP K30 were developed by solvent evaporation method. Poloxamer 407, surfactant carrier was incorpor...

The present study investigates the effect of crystalline and amorphous carriers for the improvement of dissolution profile of broad spectrum antifungal agent Itraconazole. A comparative study was performed to estimate the ability of Poloxamer-407 (crystalline carrier) and modified Gum Karaya (amorphous carries) for enhancing the dissolution profile of Itraconazole (BCS class II). Solid dispersi...

Fenoterol HBr is a bronchodilator known to be subject to first pass effect after oral administration. The aim of this study was to prepare and evaluate fenoterol HBr suppositories. Suppositories were prepared by a fusion method using different fatty bases, viz. Witepsol H15, Witepsol E75, Suppocire AP, and Suppocire BM, as well as different hydrophilic bases, viz. polyethylene glycol and poloxa...

BACKGROUND The aim of this study was to compare the pharmacokinetic properties of sodium ibuprofen and ibuprofen acid incorporating poloxamer with standard ibuprofen acid tablets. METHODS Twenty-two healthy volunteers were enrolled into this randomised, single-dose, 3-way crossover, open-label, single-centre, pharmacokinetic study. After 14 hours' fasting, participants received a single dose ...

In this study, we investigated the hypolipidemic effects of Sophora flavescens in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. The MeOH extract and 4 fractions of S. flavescens were administered at doses of 250 and 100 mg/kg body weight, respectively, once a day for 3 d to the poloxamer 407-induced hyperlipidemic rats. Serum lipid levels such as total cholesterol (TC), triglyc...

The purpose of this study was to evaluate the in vitro release and ex vivo penetration of baclofen following incorporation into a 2% poloxamer lecithin organogel. Franz cells were utilized for both the release and penetration studies. Semi-permeable dialysis membranes were used as the model skin for the penetration study. Baclofen release and penetration at predetermined time points were assess...

The objective of this study was to develop an injectable in situ forming gel system based on Poloxamer for sustained release of Astragalus polysaccharide (APS), thus achieved once or twice administration instead of frequent dosing during long-term treatment. The optimal formulation is 10 g APS, 18 g poloxamer 407, 2 g poloxamer 188, 0.15 g CMC-Na, 0.85 g sodium chloride in 100 ml gel in situ wh...

The aim of the study was to evaluate a hot-melt technique for preparation of immediate release spherical microparticles containing clarithromycin with acceptable characteristics and process yield. A modified fluid bed apparatus with rotor insert was used to prepare spherical microparticles in the size range of 125-355 µm. Poloxamer 188, PEG-32 glyceryl laurate (Gelucire 44/14) and a mixture of ...

OBJECTIVES The aim of the study was to prepare a sublingual formulation for piroxicam using a thermosensitive polymer and to evaluate its permeation through porcine sublingual mucosa. METHODS Formulation technique utilized the transition property of poloxamer from solution state at room temperature to gel state at oromucosal temperature (37 °C). The permeation of the drug was evaluated using ...

The main aim of the present investigation was to develop in situ gelling mucoadhesive liquid suppositories of ondansetron by using mucoadhesive polymers such as sodium alginate, methyl cellulose and polyvinylpyrrolidone. Polyethylene glycol was used to modify gelation temperature. Mucoadhesive liquid suppositories of ondansetron were prepared by adding mucoadhesive polymers (0.8% w/w) to the fo...