نتایج جستجو برای: poly ic
تعداد نتایج: 107020 فیلتر نتایج به سال:
Adjuvants are critical for the success of vaccines. Agonists of microbial pattern recognition receptors (PRRs) are promising new adjuvant candidates. A mechanism through which adjuvants enhance immune responses is to stimulate innate immunity. We studied the innate immune response in humans to synthetic double-stranded RNA (polyinosinic:polycytidylic acid [poly IC] stabilized with poly-L-lysine...
Liver-derived (LD) murine colon adenocarcinoma MCA-38 cells in jected into the ileocolic vein (ICV) of C57BL/6 mice developed distinct hepatic foci within 14-21 days and survived for an average of 19-35 days. In contrast, C57BL/6-nu/ni/ mice given injections of LD-MCA cells by the same route did not develop hepatic lesions. Furthermore, '"Inlabeled LD-MCA-38 tumor cells were rapidly taken up by...
Liver-derived (LD) murine colon adenocarcinoma MCA-38 cells injected into the ileocolic vein (ICV) of C57BL/6 mice developed distinct hepatic foci within 14-21 days and survived for an average of 19-35 days. In contrast, C57BL/6-nu/nu mice given injections of LD-MCA cells by the same route did not develop hepatic lesions. Furthermore, 111In-labeled LD-MCA-38 tumor cells were rapidly taken up by...
Environmental factors, such as viral infection, have been implicated in the destruction of beta-cells during the development of autoimmune diabetes. Double-stranded RNA (dsRNA), produced during viral replication, is an active component of a viral infection that stimulates antiviral responses in infected cells. Previous studies have shown that treatment of rat islets with dsRNA in combination wi...
Individuals with neurodevelopmental disorders, such as schizophrenia and autism spectrum disorder, exhibit various sleep circadian rhythm disturbances that often persist worsen throughout the lifespan. To study interaction between disruption we utilized a mouse model based on prenatal maternal immune activation (MIA). We hypothesized MIA exposure would lead to impaired locomotor activity rhythm...
Innate immune receptors that recognize nucleic acids, such as TLRs and RNA helicases, are potent activators of innate immunity that have been implicated in the induction and exacerbation of autoimmunity and inflammatory arthritis. Polyriboinosine-polyribocytidylic acid sodium salt (poly(IC)) is a mimic of dsRNA and viral infection that activates TLR3 and the RNA helicases retinoic acid-induced ...
Autism spectrum disorders are neurodevelopmental disorders characterized by two core symptoms; impaired social interactions and communication, and ritualistic or repetitive behaviors. Both epidemiological and biochemical evidence suggests that a subpopulation of autistics may be linked to immune perturbations that occurred during fetal development. These findings have given rise to an animal mo...
An efficient use of plasticizers in rubber compounds requires an understanding their miscibility behavior. Besides the chemical properties both and plasticizer, rigidity plasticizer plays important role for miscibility. The is investigated here using glass transition measured by differential scanning calorimetry broadband dielectric spectroscopy (BDS). Additionally, interfacial relaxation phase...
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