Nanoparticle formulation is a recently developed drug delivery technology with enhanced targeting potential. Nanoparticles encapsulate the of choice and delivers it to target via molecules (ex. antigen) located on nanoparticle surface. can even be targeted deeply penetrating tissue modeled deliver drugs through blood brain barrier. These advancements are providing better disease such as cancer ...

The ability to control the micelle size of poly(lactic acid) and poly(ethylene glycol) (PLA–PEG) block copolymers is important for controlling their circulation in blood cell recognition, drug release and therapeutic effects. We successfully controlled the micelle size by changing the block number of copolymers (multiblock index). PLA–PEG multiblock copolymers with multiblock indexes ranging fr...

Lactic acid is one of the top 30 potential building-block chemicals from biomass, of which the most extensive use is in the polymerization of lactic acid to poly-lactic-acid (PLA). To reduce the cost of PLA, the search for cheap raw materials and low-cost process for lactic acid production is highly desired. In this study, the final titer of produced L-lactic acid reached a concentration of 185...

Abstract The ratio of poly(lactic acid) (PLA), poly(butylene adipate- co -terephthalate) (PBAT), and calcium carbonate (CaCO 3 ) fillers in PLA/PBAT/CaCO composites was set at 90/10/5, 70/30/5, 30/70/5. effect nano- micro-CaCO on the melting crystallization performance investigated by differential scanning calorimetry. PLA related to PBAT ratio, cooling rate, CaCO particle size composites. Nano...

The management of fishery residues and plastics is considered to be a vital strategy for conserving resources and maintaining the quality of the environment. Poly(L-lactic acid) (PLA) is a commercially promising, renewable, and biodegradable plastic. In this study, a PLA depolymerase was produced in a squid pen powder (SPP) and recycled plastic waste (PLA powder)-containing medium by Pseudomona...

Poly(lactic acid) is a promising biopolymer but due to its low heat deflection temperature, the usage of PLA-based products limited. In case bulk products, annealing an effective way increase temperature. Our aim was improve temperature poly(lactic foams by annealing. this study, we showed that D-lactide content affects crystallinity foam structures in same it PLA. Lower resulted higher degree ...

Objective
 This study aims to synthesize and characterize the
 nanocomposite films incorporating unmodified and
 modified nanoparticles within the poly(lactic acid)
 matrix, investigate their usage as an alternative
 scaffold for tissue engineering.
 Materials Methods
 Titanium dioxide (TiO2) were firstly
 grafted by L-lactic acid oligomer (LA-g-TiO2) mix...

Biodegradable carriers containing gentamicin for local treatment of bone infection were developed. This paper describes the preparation and in vitro evaluation of these biodegradable implants. Poly-L-lactic acid (PLA) and poly-L-lactic acid:polyethylene glycol (PLA/PEG) disk implants containing gentamicin sulphate were obtained by compression of microspheres prepared by a double emulsion proces...

Two types of graphene-nanoplatelets (GNP-M and GNP-C) were incorporated in PLA (poly(lactic acid)) by melt blending. Materials were biodegraded during 6 months and characterized by XRD, tensile tests, DMA and biocompatibility assays. For both fillers, low loadings (0.25 wt.%) improved mechanical properties and decreased their decay until 6 months biodegradation. PLA degradation decreased its to...

A green approach is proposed to achieve a rapid surface functionalization of microcrystalline cellulose (MCC) in 30 min by solvent-free "grafting from" reaction l-lactide through compression molding without the need for an inert atmosphere. sufficient hydrophobization MCC achieved with amount grafted poly(l-lactic acid) (PLLA) oligomers 7 wt % respect MCC. The obtained MCC-g-PLLA subsequently m...