BACKGROUND Efficient delivery of anticancer chemotherapies such as paclitaxel (PTX) can improve treatment strategy in a variety of tumors such as breast and ovarian cancers. Accordingly, researches on polymeric nanomicelles continue to find suitable delivery systems. However, due to biocompatibility concerns, a few micellar nanoformulations have exquisitely been translated into clinical uses. H...

Many wounds heal slowly and are difficult to manage. Therefore Negative Pressure Wound Therapy (NPWT) was developed where polymer foams are applied and a defined negative pressure removes wound fluid, reduces bacterial burden and increases the formation of granulation tissue. Although NPWT is used successfully, its mechanisms are not well understood. In particular, different NPWT dressings were...

Three types of stearyl poly(ethylene oxide) (SPEO) with Mn of 2,300, 6,000 and 12,000 were synthesized; accordingly, three types of amphiphilic coupling-polymer SPEO-MDI-SPEO (MSPEO) were prepared by the reactions with 4,4'-methylene diphenyl diisocyanate (MDI). As the surface-modifying additives (SMA), MSPEOs were coated onto the outer wall of the medical guiding catheters. Due to the lack of ...

An oroantral communication (OAC) is an open connection between the oral cavity and maxillary sinus. Closure of OACs is commonly performed with a surgical procedure using a mucoperiosteal flap. An alternative technique using synthetic biodegradable polyurethane (PU) foam for closure of OACs is presented. This PU foam is composed of hard urethane segments, and soft segments made of D/L lactide (5...

The theory of gelation is tested by the recent experiments in poly(urethane) network. The result supports strongly the physical soundness of the theory.

A hybrid methodology is used to combine the favorable properties of non-isocyanate polyurethanes (NIPUs) in side chains with poly(methacrylates) as backbone into thermoset resins hydroxyurethane linkages (HNIPU)s. Using NIPUs avoids use toxic isocyanates poly(urethane) segments. The synthesized from cyclic carbonated copolymer templates derived atom transfer radical polymerization (ATRP) an alk...

Polyglycerols are a class of multifunctional polymers obtained from the polymerization glycidol and its derivatives. Unlike poly(ethylene glycol) (PEG), which is most common polyether, polyglycerols can exhibit many functionalities on their side chains be renewable resources, mainly glycerol. Hereby, this study will focus glycidyl carbamates, new monomers readily available glycerol carbonate, c...