The synthesis of non-racemic 5-membered cyclic carbonates from abundant alcohols is reported. Conversion the alcohol into an azanyl carbonate followed by a chiral-at-ruthenium catalyzed cyclization to provide chiral in yields up 95% and with 99% ee. This new synthetic method proposed proceed through nitrene-mediated intramolecular C(sp 3 )−H oxygenation which includes very unusual 1,7-hydrogen ...

A series of the functionalised pillar[5]arene ureidopyrimidinone derivatives were successfully synthesised by condensation reaction mono-amido-functionalised pillar[5]arenes with 2-(1-Imidazolylcarbonylamino)-6-methyl-4-pyrimidinone in dry chloroform. 1H NMR, 2D NOESY spectra and single crystal structure clearly indicated that novel [1]rotaxanes formed insertion longer alkylene chain into cavit...

The advancement of gene-based therapeutics to the clinic is limited by the ability to deliver physiologically relevant doses of nucleic acids to target tissues safely and effectively. Over the last couple of decades, researchers have successfully employed polymer and lipid based nanoassemblies to deliver nucleic acids for the treatment of a variety of diseases. Results of phase I/II clinical ...