Polycystic ovary syndrome is the most common cause of anovulatory infertility. Anovulation in polycystic ovary syndrome is characterized by the failure of selection of a dominant follicle with arrest of follicle development at the 5-10 mm stage. In an attempt to elucidate the mechanism of anovulation associated with this disorder we have investigated at what follicle size human granulosa cells ...

The prevalence of polycystic ovaries in the women who had had recurrent miscarriages was high (82%). Although the number of parous control women was small, their prevalence of polycystic ovaries (18%) was similar to that observed in a much larger population of normal women (22%).3 The normal serum luteinising hormone and urine pregnanediol-3a-glucuronide concentrations suggest that the endocrin...

Polycystic ovary syndrome affects 5-10% of women in the developed world, making it the most common endocrine disorder among women of reproductive age. The symptoms typically associated with polycystic ovary syndrome: amenorrhea, oligomenorrhea, hirsutism, obesity, subfertility, anovulation and acne can lead to a significant reduction in female life quality.The aim of the study was to evaluate t...

the association of secreted frizzled related protein type 4 (sfrp4) as an antagonist of wnt mole-cules in apoptotic events has been reported previously. moreover, its increased expression has been reported in the ovary of women with polycystic ovary (pco). we have demonstrated in-creased sfrp4 in pco-induced rat ovary related to an increased number of apoptotic follicles showing nuclear ?cateni...

Polycystic Ovary Syndrome (PCOS) is a heterogenous disorder [1] characterized by oligoanovulation with clinical or biochemical hyperandrogenemia [2]. 5-10% of women in reproductive age group are affected [3]. The estimated prevalence of polycystic ovaries as diagnosed by ultrasonography in normal population is more than 20% [4-6]. PCOS has been said to be a spectrum disease with asymptomatic po...

Acquired polycystic kidney disease occurs as one of the sequelae of chronic haemodialysis. Spontaneous perirenal haemorrhage of acquired polycystic kidney disease in a patient on chronic haemodialysis is an uncommon clinical entity [1–4], and bilateral perirenal haemorrhage in these patients is rare [5]. This report describes one case of bilateral perirenal haemorrhage in a haemodialysis patien...

45 female patients with polycystic ovary syndrome took thioctic acid (Thioctacid-HR), 600 mg (n = 25) or high protein diet (n = 20). Fast insulin and glucose stimulus insulin were investigated before and after 3 months taken treatment. The use of thioctic acid, 600 mg is a new effective pathogenetics therapy of polycystic ovary syndrome on influence of hyperinsulinemia, HOMA-IR index and ovary ...

A 44 years old male patient with acute coronary syndrome and polycystic kidney disease is described. Coronary angiography showed ectatic coronary arteries. Polycystic kidney disease is the most common inherited kidney disorder which is commonly associated with extra renal manifestations including cardiovascular conditions. Involvement of vessels may lead to arterial aneurysms which most commonl...

introduction: autosomal dominant polycystic kidney disease (adpkd) is one of the most common genetic kidney disorders with the incidence of 1 in 1,000 births. adpkd is genetically heterogeneous with two genes identified: pkd1 (16p13.3, 46 exons) and pkd2 (4q21, 15 exons). eighty five percent of the patients with adpkd have at least one mutation in the pkd1 gene. genetic studies have demonstrate...