A 26-year-old female patient suffered from intermittent back pain for 4 years and a fall from bicycle aggravated the symptom. Physical and imaging examinations revealed the diagnosis of polyostotic fibrous dysplasia in McCune-Albright syndrome. No neurological symptom was found. A vertebral fracture was seen at the eighth thoracic body. Percutaneous kyphoplasty was performed at the fractured le...

The syndrome of McCune-Albright syndrome (MAS) is clasically defined as a triad presentation with the findings of polyostotic fibrous dysplasia, café-au-lait spots, and sexual precocity. However, not all patients present with complete symptoms. A 52-year-old man was diagnosed as having a variant of McCune-Albright syndrome with the following findings: polyostotic fibrous dysplasia, acromegaly d...

Fibrous dysplasia is a benign fibroosseous lesion characterised by the replacement of normal bone by excessive proliferation of cellular fibrous connective tissue which is slowly replaced by bone, osteoid, or cementum-like material. It causes bone pain, deformities, and pathological fractures. Fibrous dysplasia (FD) is a sporadic benign skeletal disorder that can affect one bone (monostotic for...

Fibrous dysplasia is a benign intramedullary lesion characterized by an excessive proliferation of cellular fibrous tissue intermixed with irregular trabeculae. It involves any of the bones presenting as monostotic, polyostotic, or panostotic lesion. It is caused by mutation in the GNAS1 gene (20q13.2, encoding a G-protein) resulting in inhibition of intrinsic GTPase activity of Gs alpha protei...

Fibrous dysplasia is abnormal proliferation of fibrous tissue interspersed with normal or immature bone. The records of 11 cases of fibrous dysplasia of paranasal sinuses with skull base involvement were reviewed. Six patients were polyostotic and 5 were classified as monostotic fibrous dysplasia. Four cases were managed endoscopically and only 1 patient had undergone right lateral craniotomy f...

McCune-Albright syndrome is characterized by the triad café-au-lait cutaneous spots, polyostotic fibrous dysplasia and endocrinopathies. This article presents two cases of McCune-Albright syndrome in a middle-aged woman and a young girl. Both patients presented café-au-lait spots on the face and other parts of the body and expansion of the mandible with radiopaque-radiolucent areas with ground-...