A novel antimicrobial peptide, GAPI, has been developed recently by grafting gallic acid (GA) to polyphemusin I (PI). The objective of this study was investigate the antibacterial effects GAPI on common oral pathogens. This laboratory used minimum inhibitory concentrations and bactericidal assess properties against Transmission electron microscopy examine bacterial morphology both before after ...

Editorial Periodontal diseases have long been associated with an increased, yet moderate, risk for the development of atherosclerosis and coronary heart disease. The postulated mechanism underlying this association is the low grade systemic inflammatory response to pathogens engaged in chronic periodontal infection, such as Porphyromonas gingivalis, which may facilitate atheroma formation and t...

background. the most common species isolated from primary endodontic infections are black-pigmented bacteria. these species are implicated in apical abscess formation due to their proteolytic activity and are fastidious in nature. therefore, the present study was carried out to evaluate the presence and identification of various pigmented porphyromonas and prevotella species in the infected roo...

Lipopolysaccharide (LPS) from Porphyromonas gingivalis prevented apoptosis of HL60-derived neutrophils, which could not be restored upon the addition of interleukin-10. Signaling of P. gingivalis LPS through Toll-like receptor 2 (TLR2), not TLR4, may account for the inhibiting effect of P. gingivalis LPS on apoptosis and provide a mechanism for the development of destructive periodontal inflamm...

OBJECTIVES Interest in periodontitis as a potential risk factor for atherosclerosis and its complications resulted from the fact that the global prevalence of periodontal diseases is significant and periodontitis may induce a chronic inflammatory response. Many studies have analyzed the potential impact of the Porphyromonas gingivalis, major pathogen of periodontitis, on general health. The pur...

The capsular polysaccharide (CPS) of the periodontal pathogen Porphyromonas gingivalis is an important virulence factor for this organism. We purified P. gingivalis CPS, immunized mice with this antigen, and assessed the vaccine potential of P. gingivalis CPS by using the murine oral challenge model. Animals immunized with P. gingivalis CPS developed elevated levels of immunoglobulin M (IgM) an...

conclusions p. gingivalis and p. intermedia could play a role in implant failure by changing the expression profiles of genes related to bone formation and resorption. results viability was reduced to 56.8% (p. gingivalis) and 52.75% (p. intermedia) at 1000 multiplicity. amongst 48 genes examined, expressions of bmper, smad1, il8 and nfrkb were found to be highly upregulated by both bacterial c...

the plant salvadora persica is used for oral hygiene in many parts of the world. it has been suggested that it has antibacterial properties, in addition to its ability to mechanically remove plaques. the aim of this study was to assess the antimicrobial activity of the herbal product persica containing salvadora persica against periodontopathogens porphyromonas gingivalis and aggregatibacter ac...

Binding of Streptococcus oralis glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to Porphyromonas gingivalis fimbriae was characterized via a biomolecular interaction analysis system. The interaction was specific, and the association constant value was 4.34 x 10(7) M(-1), suggesting that S. oralis GAPDH functions as a dominant receptor for P. gingivalis and contributes to P. gingivalis coloniza...