Human immunoglobulin M (IgM) rheumatoid factors (RFs) show primary direct enzyme-linked immunosorbent assay (ELISA) reactivity with Fab rather than Fc fragments of monoclonal antibody (mAb) II-481 directed against the Fc gamma-binding site of herpes simplex virus glycoprotein gE. This preferential anti-Fab specificity suggests that RFs react with antigen-binding portions of mAb II-481 as anti-i...

The paper [Tarski:Les fondements de la géométrie des corps,Annales de la Société Polonaise de Mathématiques, pp. 29–34, 1929] is in many ways remarkable. We address three historico-philosophical issues that force themselves upon the reader. First we argue that in this paper Tarski did not live up to his own methodological ideals, but displayed instead a much more pragmatic approach. Second we s...

background and objective: due to contagiousness of pertussis, a rapid and sensitive method for diagnosis is required to initiate the treatment and interrupt its transmission. materials and methods: to detect b. pertussis strains, we used two real-time pcr targeting is 481 and bp283 sequences and compared factors influencing culture and real-time pcr results. results: totally, 779 specimens were...

Earlier studies have shown that the herpes simplex virus (HSV) U(S)3 encodes two transcriptional units directing the synthesis of the U(S)3 (residues 1 to 481) and U(S)3.5 (residues 77 to 481) protein kinases. Both kinases phosphorylate histone deacetylase 1 (HDAC1) and HDAC2 and enable the expression of genes cotransduced into U2OS cells by recombinant baculoviruses, an activity designated the...

The mortality of burn patients remains high in spite of the advances made in treating initial burn shock, controlling burn wound infection, and providing nutritional support. Smoke inhalation is recognized as a strong determinant of morbidity and mortality in burn patients, and most burn patients die because of associated inhalation injury. There are many reports on this combined injury (cutane...