Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is being studied intensively for its role in carcinogenesis and in mediating the effects of prostate cancer treatment and prevention drugs. Prostate cancers express abundant and higher constitutive levels of PPAR-gamma than do normal prostate cells and are growth inhibited by ligand activation of PPAR-gamma. However, little is known ...

Objectives—Peroxisome proliferator-activated receptor / (PPAR / ) is a nuclear receptor found in platelets. PPAR / agonists acutely inhibit platelet function within a few minutes of addition. As platelets are anucleated, the effects of PPAR / agonists on platelets must be nongenomic. Currently, the particular role of PPAR / receptors and their intracellular signaling pathways in platelets are n...

Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has been shown to be immunoregulatory in autoimmune diseases by inhibiting production of a number of inflammatory mediators. We investigated whether PPAR-γ gene deletion in hematopoietic cells would alter disease pathogenesis in the antiglomerular basement membrane (anti-GBM) mouse model. PPAR-γ...

Natural and synthetic agonists of the peroxisome proliferatoractivated receptor (PPAR ) regulate adipocyte differentiation, glucose homeostasis, and inflammatory responses. Although effects on adipogenesis and glucose metabolism are genetically linked to PPAR , the PPAR dependence of antiinflammatory responses of these substances is less clear. Here, we have used a combination of mRNA expressio...

Background—The peroxisome proliferator–activated receptor(PPAR ) plays important roles in lipid metabolism, inflammation, and atherosclerosis. PPAR ligands have been shown to reduce cardiovascular events in high-risk subjects. PPAR expression by arterial cells, including macrophages, may exert local antiatherogenic effects independent of plasma lipid changes. Methods and Results—To examine the ...

Peroxisome proliferator-activated receptors (PPARs) are transcription factors that belong to the nuclear hormone receptor superfamily. PPAR and PPAR ligands have been demonstrated to exert anti-inflammatory activities in macrophages by repressing the activities of several transcription factors. PPAR is expressed in T lymphocytes and may play a role in cytokine production, cellular proliferation...

Peroxisome proliferator-activated receptor (PPAR) is an important signaling molecule in cells of mesenchymal origin, inducing differentiation and regulating cell proliferation in several cell types such as vascular smooth muscle cells. Leiomyomas arise from smooth muscle cells of the uterine myometrium with an incidence rate as high as 70% in women of reproductive age. PPAR signaling has not be...

Peroxisome proliferators-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. The three PPAR isoforms (alpha, gamma and beta/delta) have been found to play a pleiotropic role in cell fat metabolism. Furthermore, in recent years, evidence has been found regarding the antiproliferative, proapoptotic, and differentiation-pr...

Peroxisome proliferator-activated receptor-gamma (PPAR)-gamma is a ligand-activated transcriptional factor belonging to steroid receptor superfamily. PPAR-gamma plays a role in both adipocyte differentiation and tumorigenesis. Up to date, PPAR-gamma is expressed in various cancer tissues, and PPAR-gamma ligand induces growth arrest of these cancer cells. In this study, we examined the expressio...