BACKGROUND/AIMS Paraquat (PQ) has been used in suicide attempts; an estimated 2,000 toxic ingestions occur annually, with 60-70% mortality. We sought to determine why PQ is such a common agent for suicide attempts in Korea. METHODS We analyzed 250 cases (143 males, 107 females) of attempted suicide by PQ ingestion from January to December 2007. The procurement of the PQ was divided into two c...

The herbicide paraquat (PQ) has increasingly been reported in epidemiological studies to enhance the risk of developing Parkinson's disease (PD). Furthermore, case-control studies report that individuals with genetic variants in the dopamine transporter (DAT, SLC6A) have a higher PD risk when exposed to PQ. However, it remains a topic of debate whether PQ can enter dopamine (DA) neurons through...

OBJECTIVE The aim of this study was to explore the effects of selenium (Se) on locomotor activity and DNA damage in a rat model of Parkinson's disease (PD) induced by paraquat (PQ). METHODS Forty-eight male Wistar rats were divided into four groups: control group (n = 12), Se group (n = 12), PQ group (n = 12), and Se + PQ group (n = 12). PQ was administered intraperitoneally (10 mg/kg). Se wa...

Experimental evidence suggested that sodium ferulate (SF) and oxymatrine (OMT) combination had synergistic anti-inflammatory and antioxidant effects. We hypothesized that SF and OMT combination treatment might have protective effects on paraquat-induced acute lung injury. In our study, the Swiss mice were randomly divided into seven groups, including control, paraquat (PQ), SF (6.2 mg/kg/day); ...

OBJECTIVE The aim of this study was to use antimicrobial efficacy endpoint methodology to determine compatibility of multipurpose disinfecting solutions (MPSs), lens cases, and hydrogel lenses for disinfection (AEEMC) against International Organization for Standardization (ISO)-specified microorganisms and clinical ocular isolates of Stenotrophomonas maltophilia. METHODS Six MPSs (PQ/Aldox 1,...

A bstract We show that the strong CP problem is solved in a large class of compactifications string theory. The Peccei-Quinn mechanism solves if CP-breaking effects ultraviolet completion gravity and QCD are small compared to CP-preserving axion potential generated by low-energy instantons. characterize both classes effects. To understand quantum gravitational effects, we consider an ensemble f...

Acute paraquat (PQ) toxicity induces redox cycling leading to fatality in both man and animals with clinical management being supportive therapy due lack of specific effective antidote. This study thus aimed at determining the sero-biochemical pathological changes induced by acute PQ administration male rats mitigating role sodium selenite. Forty were used for grouped into 5 eight viz: Group I ...

To achieve frequency separation between actuators of a dual-stage servo actuator system in a hard disk drive, the PQ control design method can be used. In the PQ method, the servo controller is designed by focusing on structural interference of the actuators. This paper provides a specific parametrization for fixed order feedback controllers used in the PQ-method for which the structural interf...

Plasmodium vivax is the most prevalent of the five species causing malaria in humans. The current available treatment for P. vivax malaria is limited and unsatisfactory due to at least two drawbacks: the undesirable side effects of primaquine (PQ) and drug resistance to chloroquine. Phenylalanine-alanine-PQ (Phe-Ala-PQ) is a PQ prodrug with a more favorable pharmacokinetic profile compared to P...

experimental evidence suggested that sodium ferulate (sf) and oxymatrine (omt) combination had synergistic anti-inflammatory and antioxidant effects. we hypothesized that sf and omt combination treatment might have protective effects on paraquat-induced acute lung injury. in our study, the swiss mice were randomly divided into seven groups, including control, paraquat (pq), sf (6.2 mg/kg/day); ...