The aim of the study was to evaluate the double modality working of a new autofluorescence videobronchoscope SAFE-3000 for the detection and localization of precancerous and malignant lesions. From April to May 2009, 168 patients underwent SAFE-3000 bronchoscopy using 'Twin Mode' and 'Multiple Image Xposition (MIX)' technologies. The study considers only 97 patients with morphological alteratio...

At present, it is difficult to identify a gold standard for endoscopic staging of laryngeal cancer, especially considering the large number of endoscopic instruments available. We have coined the term multistep endoscopy to describe a method for staging laryngeal precancerous and neoplastic lesions that sequentially uses several endoscopic tools including high definition white light endoscopy (...

In the 3 decades from 1910 to 1940, more progress took place in cancer research and the diagnosis and treatment of cancers than during the prior centuries combined. The discovery of several carcinogens, precancerous conditions, and hereditary cancers adduced new thoughts about the genesis of cancers. Even though diagnostic radiology and radiation therapy became apposite specialties, surgery ret...

introduction: oral premalignant lesions are conditions having high potential tendency for transformation into malignancy. the use of a conservative and effective treatment modality is one of the best strategies for cancer prevention. photodynamic therapy (pdt) is a non-invasive method for topical and selective treatment of oral precancerous lesions. the present study was taken up to determine t...

Surveillance decisions for gastric cancer [GC] mostly focused on advanced-stage lesions and were made based baseline severity/extension diagnosis of non-neoplastic according to current guidelines. However, misclassification may occur due sampling error or endoscopy quality in practice. We aimed develop a simple risk-stratification strategy aid the decision-making surveillance. In multicenter co...

introduction: different oral lesions have clinical characteristics which in some cases are similar. therefore, in these cases histopathological examination for correct diagnosis is necessary. the aim of this study was to evaluate the compatibility rate of clinical and histopathological diagnosis of oral lesions in zahedan school of dentistry. methods: in this retrospective study, determination ...

introduction: as a result of aging process, oral mucosa becomes susceptible to oral diseases. having knowledge about prevalence and distribution of geriatric oral diseases is essential for prevention and treatment planning. this study aimed to evaluate the prevalence of geriatric patients' oral biopsies in specimens obtained in medical centers of zahedan university of medical sciences. methods:...

background and aims. many oral squamous cell carcinomas develop from potentially malignant disorders (pmds) which include a variety of lesions and conditions characterized by an increased risk for malignant transformation. this study evaluated the quantitative expression of egfr in normal oral mucosa, oral leukoplakia and oral submucous fibrosis to predict the malignant risk in compliance with ...

A micronucleus is an additional small nucleus formed due to chromosomes or chromosomal fragments fail to be incorporated into the nucleus during cell division. In this study, we assessed the utility of micronucleus counting as a screening tool in cervical precancerous lesions in Thinprep cytological test smears under oil immersion. High risk HPV was also detected by hybrid capture-2 in Thinprep...

PURPOSE Autofluorescence imaging is increasingly used to noninvasively identify neoplastic oral cavity lesions. Improving the diagnostic accuracy of these techniques requires a better understanding of the biological basis for optical changes associated with neoplastic transformation in oral tissue. EXPERIMENTAL DESIGN A total of 49 oral biopsies were considered in this study. The autofluoresc...