Let me start by thanking Professors Santorio and Szabo for their insightful comments careful readings of Conjoining Meanings (CM). They highlight the main theses describe project in helpful ways.1 So instead multiplying summaries, let say a little about what motivated project. Chomsky was influential. But teaching truth-theoretic semantics, many years, really convinced need different conception...

BACKGROUND The need for high-quality evidence that is applicable in real-world, routine settings continues to increase. Pragmatic trials are designed to evaluate the effectiveness of interventions in real-world settings, whereas explanatory trials aim to test whether an intervention works under optimal situations. There is a continuum between explanatory and pragmatic trials. Most trials have a...

Randomised trials are hard work. Like much that is hard, this toil is only worth it because of the prospect of a substantial reward. Sadly, the reward to potential users such as patients, healthcare professionals and policy makers is often smaller than it should be because trial design decisions reduced the relevance of the trial to them. PRECIS-2 is a tool designed to help trialists match thei...