In this forward-facing review, we briefly summarize what we see as the state of modern cardiovascular genetics and genomics before outlining some of the key areas in which we believe there is a need for investment if we are to realize the full clinical potential of the field. There is clearly substantial overlap with the field of precision medicine, yet it may be in understanding where genetics...

For precision medicine to become a reality, we propose 3 changes. First, healthcare deliverables must be prioritized, enabling translation of knowledge to the clinic. Second, physicians and patients must be convinced to participate, requiring additional infrastructure in health systems. Third, discovery science must evolve to shift the preclinical landscape for innovation. We propose a change i...

In this issue of The Oncologist, we begin a series of articles that consider the often problematic challenge of understanding and applying genomic information to the practice of oncology. Bardia et al. [1] describe the genomic findings from a patient with estrogen receptor (ER)-positive breast cancer after progression on hormonal therapy. In this case, tumor profiling revealed an ESR1 mutation ...

sunn pest, eurygaster integriceps put., is the most important pest of wheat and barley in most producing regions of iran, including lorestan province. spatial distribution and fixed precision sequential sampling plans of sunn pest by the use of two quadrate sizes 0.25 and 0.5 m2 were investigated in rainfed wheat fields in borujerd during 2004 and 2005. based on r square of regression, taylor&a...

personalized medicine is a set of diagnostic, prognostic and therapeutic approaches in which medical interventions are carried out based on individual patient characteristics. as life expectancy increases in developed and developing countries, the incidence of diseases such as cancer goes up among people in the community. cancer is a disease that the response to treatment varies from one person...

objective: retention and resistance of the implant-tissue supported overdenture may be affected by the type of attachment. the aim of this research was to compare the retention and resistance of nobel biocare ball (nbb), nobel biocare bar and clip (nbbc) and sterngold era red (erar) attachments on an implant-tissue supported overdenture model. materials and methods: the attachment samples were ...