نتایج جستجو برای: precursors

تعداد نتایج: 39041  

2007
Stuart A. Nicklin Andrew H. Baker Simon N. Waddington Menzo J. E. Havenga Alan L. Parker John H. McVey Jessica H. Doctor Oscar Lopez-Franco

Journal: :Journal of thrombosis and haemostasis : JTH 2015
D C Wood L A Pelc N Pozzi M Wallisch N G Verbout E I Tucker A Gruber E Di Cera

BACKGROUND The production of therapeutically relevant proteases typically involves activation of a zymogen precursor by external enzymes, which may raise regulatory issues about availability and purity. Recent studies of thrombin precursors have shown how to engineer constructs that spontaneously convert to the mature protease by autoactivation, without the need for external enzymes. OBJECTIV...

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