In 2010, approximately one in three U.S. adults aged≥20 years (an estimated 79 million persons) had prediabetes, a condition in which blood glucose or hemoglobin A1c (A1c) levels are higher than normal but not high enough to be classified as diabetes. Persons with prediabetes are at high risk for developing type 2 diabetes, which accounts for 90%-95% of all cases of diabetes. Each year, 11% of ...

Abstract Background Prediabetes is characterized by a hemoglobin A1c of 5.7–6.4% and fasting blood glucose 100–125 mg/dl. A high percentage prediabetes subjects develop type 2 diabetes mellitus in the next years. The effects opioid peptides their receptors, addition to immunological cytokines, on are not well understood. Therefore, molecular, physiological, clinical studies required link system...

In California, more than 13 million adults (46 percent of all adults in the state) are estimated to have prediabetes or undiagnosed diabetes. An additional 2.5 million adults have diagnosed diabetes. Altogether, 15.5 million adults (55 percent of all California adults) have prediabetes or diabetes. Although rates of prediabetes increase with age, rates are also high among young adults, with one...

The aggregation of human amylin (hA) to form cytotoxic structures has been closely associated with the causation of type 2 diabetes. We sought to advance understanding of how altered expression and aggregation of hA might link β-cell degeneration with diabetes onset and progression, by comparing phenotypes between homozygous and hemizygous hA-transgenic mice. The homozygous mice displayed eleva...

BACKGROUND Type 2 diabetes mellitus (T2DM) is a major global health problem. An estimated 20%-50% of diabetic subjects in Canada are currently undiagnosed, and around 20%-30% have already developed complications. Screening for high blood glucose levels can identify people with prediabetic conditions and permit introduction of timely and effective prevention. This study examines the benefit of s...

More than 100 million Americans have prediabetes or diabetes. Prediabetes is a condition in which individuals have blood glucose levels higher than normal but not high enough to be classified as diabetes. People with prediabetes have an increased risk of Type 2 diabetes. An estimated 34% of adults have prediabetes. Prediabetes is now recognized as a reversible condition that increases an indivi...

BACKGROUND Type 2 diabetes mellitus (T2DM) and prediabetes have increased in prevalence among overweight and obese children, with significant implications for long-term health. There is little published evidence on the best approaches to care of prediabetes among overweight youth or the current practices used across pediatric weight management programs. METHODS This article reviews the litera...

OBJECTIVE This study uses novel methods to examine the frequency of diagnosis and treatment of prediabetes in real-world clinical settings using electronic health record (EHR) data. RESEARCH DESIGN AND METHODS We identified a cohort of 358,120 adults with incident prediabetes (fasting plasma glucose [FPG] 100-125 mg/dL or glycated hemoglobin 5.7-6.4% [39-46 mmol/mol]) between 2006 and 2010 an...

INTRODUCTION The purpose of this study was to assess crude, age-adjusted, and risk-factor-specific prevalences of self-reported prediabetes and to identify factors associated with self-reported prediabetes in an adult population. METHODS Data were collected through questionnaires completed by a racially diverse sample of diabetes-free adult participants in the statewide community-based wellne...

BACKGROUND Prediabetes is an altered metabolic state of glucose; it does not present symptoms, considered intermediate stage in the progression to diabetes; possible detect early avoid or delay disease. NutrIMSS strategy was implemented so that these patients achieve a healthy lifestyle. OBJECTIVE To evaluate impact educational intervention based on somatometric and biochemical parameters with ...