Preeclampsia is a prevalent pregnancy hypertensive disease with both maternal and fetal morbidity and mortality. Emerging evidence indicates that global placental DNA hypomethylation is observed in patients with preeclampsia and is linked to altered gene expression and disease development. However, the molecular basis underlying placental epigenetic changes in preeclampsia remains unclear. Usin...

BACKGROUND Liver X receptor alpha (LXRα) and endoglin have been postulated to play roles in trophoblast invasion and lipid metabolic disturbances. However, the relationship between LXRα and endoglin levels in serum and placenta of patients with preeclampsia remains poorly understood. The objective of this study was to identify correlations between LXRα, endoglin and preeclampsia and provide new...

OBJECTIVE To determine whether there are differences in autonomic nervous system function in early- versus late-onset preeclampsia. METHODS Matched case-control study. Cases were defined as singleton pregnancies with preeclampsia at < 34+0 weeks of gestation (early-onset preeclampsia) and ≥ 34+0 weeks of gestation (late-onset preeclampsia). For each case in each of the preeclampsia subgroups,...

introduction:  preeclampsia is the common and dangerous complication of pregnancy with unknown reason. multiple causes such as depression, psychological and physical stress may be involved in its development. this study was performed to determine the relationship between anxiety during pregnancy and the incidence of preeclampsia. methods: this case-control study was conducted on 150 pregnant wo...

Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5-8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called "a disease of theories." The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analy...

OBJECTIVE To develop clinical risk tools for preeclampsia and small for gestational age (SGA) in high-risk women. METHODS Individual risk scores based on clinical risk factors were calculated using logistic regression and validated in 1687 women with obesity in first pregnancy, chronic hypertension, or previous preeclampsia. RESULTS The risk of preeclampsia varied from 7% in obese primipara...

1. Abstract 2. Introduction 3. Sodium Regulation in Uncomplicated Pregnancy 4. Sodium Regulation in Preeclampsia 5. Cell Sodium Regulation in Uncomplicated Pregnancy 5.1. Cell Sodium and Cell (Na,K)ATPase or Sodium Pump (SP) in Uncomplicated Pregnancy 5.2. Other Cell Sodium Transport Systems in Uncomplicated Pregnancy 6. Cell Sodium Regulation in Preeclampsia 6.1. Cell Sodium and Potassium in P...

Understand the effects of pregnancy on the maternal cardiovascular system. Devise a clear and rational plan for antepartum care in women with chronic hypertension. Understand the distinction between pregnancy-induced hypertension and preeclampsia, and between “mild” and “severe” preeclampsia. Discuss the risks and benefits of the various preventive strategies for women at highrisk for developin...

Shah, Dinesh M. Role of the renin-angiotensin system in the pathogenesis of preeclampsia. Am J Physiol Renal Physiol 288: F614–F625, 2005; doi:10.1152/ ajprenal.00410.2003.—Preeclampsia is a hypertensive disorder unique to pregnancy with consistent involvement of the kidney. The renin-angiotensin system (RAS) has been implicated in the pathogenesis of preeclampsia. In the gravid state, in addit...

BACKGROUND Preeclampsia is a disorder with a reported incidence of 2%-8% among all pregnancies, accounting for more than 50,000 deaths worldwide each year. In low- and middle- income countries maternal/perinatal morbidity and mortality associated with preeclampsia are high due to the lack of proper prenatal and hospital care and limited access to neonatal intensive care. The objectives of our s...